3776-39-4Relevant academic research and scientific papers
Divergent Total Syntheses of Enmein-Type Natural Products: (?)-Enmein, (?)-Isodocarpin, and (?)-Sculponin R
Pan, Saiyong,Chen, Sicong,Dong, Guangbin
, p. 6333 - 6336 (2018/04/30)
Divergent total syntheses of the enmein-type natural products (?)-enmein, (?)-isodocarpin, and (?)-sculponin R have been achieved in a concise fashion. Key features of the strategy include 1) an efficient early-stage cage formation to control succeeding diastereoselectivity, 2) a one-pot acylation/akylation/lactonization to construct the C-ring and C8 quarternary center, 3) a reductive alkenylation approach to construct the enmain D/E rings and 4) a flexible route to allow divergent syntheses of three natural products.
