3776-44-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(Naphthalen-1-yl)-3-phenylpropanoic acid is used as an anti-inflammatory agent for the treatment of conditions such as arthritis, menstrual cramps, and muscle pain. It is effective in reducing inflammation and alleviating pain by inhibiting the production of pro-inflammatory chemicals.
Used in Pain Management:
2-(Naphthalen-1-yl)-3-phenylpropanoic acid is used as a pain reliever to provide relief from various types of pain, including chronic and acute pain, by reducing inflammation and the associated discomfort.
Used in Oral Medication:
2-(Naphthalen-1-yl)-3-phenylpropanoic acid is used in the form of tablets and capsules for oral administration, making it a convenient and accessible treatment option for patients experiencing pain and inflammation.

Upstream product

• 4735-49-3 1-[(E)-2-nitroethenyl]naphthalene 
• 6921-34-2 benzylmagnesium chloride 

Relevant academic research and scientific papers

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))

Generation of nitroalkanes, hydroximoyl halides and nitrile oxides from the reactions of β-nitrostyrenes with Grignard or organolithium reagents

The β-nitrostyrenes 1 or 2 react with Grignard or organolithium reagents in ether or THF solution to generate by 1,4-addition the intermediate nitronates A. When A is treated with dilute hydrochloric acid, high yields of the nitroalkanes 3 (and oximes 4) or 5 are obtained Hydroximoyl halides 6, 8 or nitrile oxides 7 can be isolated when the intermediate A is slowly added to the ice cold concentrated hydrohalic acid. The same products 6 and/or 7 are observed if the nitronates, generated from the substrate 1a, are added to 85% aqueous H2SO4 but only the hydrolyzed carboxylic acids 9 are generated when the β-nitrostyrenes 2 are reacted with Grignard reagents and worked up under the same condition. The nitrile oxides 7 can undergo 1,3-dipolar cycloaddition with alkenes or alkynes to generate 2-isoxazolines or isoxazoles. A one-pot synthesis of the [n,3,0] bicyclic (n = 3 or 4) compounds 23-27 by intramolecular nitrile oxide-olefin cycloadditions is reported.

Reactions of β-nitrostyrenes with Grignard reagents

α-Phenyl-β-nitrostyrene 1a and β-nitrostyrene 1b react with Grignard reagents to generate hydroxyimoyl halides 3 or nitrile oxides 4 after workup with ice cold concentrated aqueous HX acid solution. Carboxylic acids 5 are the only products isolated from 1b and products 3 or 4 are still obtained from 1a when concentrated sulfuric acid solution is used.