37772-93-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Methylpyrrolidine-2,4-dione is used as a precursor in the synthesis of various organic compounds for the development of pharmaceuticals. Its ability to act as a building block allows for the creation of a wide range of biologically active molecules, contributing to the advancement of new drug discoveries.
Used in Agricultural Sector:
5-Methylpyrrolidine-2,4-dione is used as a precursor in the synthesis of various organic compounds for agricultural applications. Its potential use in this sector highlights its versatility and the possibility of developing new agrochemicals and other products that can benefit crop protection and enhancement.
Used in Research and Industrial Applications:
5-Methylpyrrolidine-2,4-dione is utilized in research and industrial applications due to its availability from various chemical suppliers. Its role as a building block in organic synthesis makes it a valuable component in the development of new compounds and products across different industries.

Upstream product

• 89776-89-6 methyl 4-hydroxy-5-methyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

Studies on the synthesis and bioactivities of 4-amino derivatives of tetramic acid

In order to study the potential bioactivities of 4-amino tetramic acid derivatives, the 4-amination products of pyrrolidine-2,4-diones (5) and 4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylates (4) were prepared. The 4-amination of 5 took place in high yield when catalyzed by acetic acid, whereas the 4-amination of 4 was achieved through a 4-ethoxy intermediate, which was prepared by acidic etherification. Their herbicidal, fungicidal, insecticidal, and antitumor activities were tested. The bioassays showed that two of the compounds exhibited good herbicidal activity against dicot Arabidopsis thaliana at a concentration of 10 μg/mL, and one compound gave instinct fungicidal activity against Pythium sp. at a concentration of 2 μg/mL.

Methods of inhibiting the advanced glycosylation of proteins using tetramic and tetronic acids and compositions therefor

The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises substituted or unsubstituted tetramic and tetronic acids capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.