37773-18-5Relevant academic research and scientific papers
Selenols: a new class of carbonic anhydrase inhibitors
Angeli, Andrea,Tanini, Damiano,Nocentini, Alessio,Capperucci, Antonella,Ferraroni, Marta,Gratteri, Paola,Supuran, Claudiu T.
supporting information, p. 648 - 651 (2019/01/25)
Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.
