37775-92-1

Upstream product

• 254100-64-6 C₃₃H₄₆NO₃PSSi 
• 38851-76-2 methyl-(1-naphthyl)(phenyl)phosphine 
• 55123-94-9 (+/-)-methyl(1-naphthyl)phenylphosphine oxide 
• 15849-86-2 methyl(phenyl)chlorophosphine 
• 703-55-9 1-naphthylmagnesiumbromide 
• 20684-97-3 chloro(diisopropylamino)(phenyl)phosphine 

Relevant academic research and scientific papers

A Novel Resolution Procedure for the Preparation of P-Stereogenic Phosphine Oxides

(Matrix Presented) A new general route for preparing enantiomerically pure P-stereogenic phosphine oxides has been developed by exploiting the Staudinger reaction between racemic tertiary phosphines and an enantiomerically pure organoazide. The resulting

METHOD FOR INCREASING THE ENANTIOMERIC EXCESS OF CHIRAL PHOSPHINE OXIDES, SULPHIDES, IMIDES AND BORANES

The present invention relates to a method for increasing the enantiomeric excess of a chiral phosphine oxide, a chiral phosphine sulphide, a chiral phosphine-borane and a chiral phosphine imide said method comprising the steps of: (a) contacting said chiral phosphine oxide, sulphide, imide or borane with a solvent to form a slurry; (b) partitioning the phosphine oxide, sulphide, imide or borane either into the solvent or as an insoluble product; and (c) optionally, isolating the partitioned phosphine oxide, sulphide, imide or borane.

CHIRAL PHOSPHORUS COMPOUNDS

A process for the stereoselective preparation of a P-chiral four-co-ordinated phosphorus compound, the process comprising reacting a first reactant selected from the group consisting of a chiral alcohol, chiral amine or chiral thiol, with a second reactan

Kinetic resolution of racemic ferrocenylphosphine compounds by enantioselective oxidation using cyclic selenoxides having a chiral ligand

Cyclic selenoxides having an optically active binaphthyl skeleton work as the reagents for enantioselective oxidation of phosphines to the corresponding phosphine oxides. Treatment of a racemic 2-oxazolin-2-ylferrocenylphosphine with one of the selenoxides in carbon tetrachloride in the presence of phenol affords the corresponding phosphine oxide together with the unreacted starting phosphine, both with moderate enantioselectivities (the phosphine oxide, up to 13% ee; the phosphine, up to 29% ee).

A simple resolution procedure using the Staudinger reaction for the preparation of P-stereogenic phosphine oxides

The resolution of a variety of (±)-P-stereogenic phosphines is achieved by exploiting the Staudinger reaction of a (±)-phosphine with enantiopure (1S,2R)-O-(tert-butyldimethylsilyl)isobornyl-10-sulfonyl azide. The resulting mixtures of diastereomeric phosphinimines are generally separable by fractional crystallization or flash chromatography. Subsequent acid-catalyzed hydrolysis provides the corresponding optically pure phosphine oxides in high yields.