37778-33-9Relevant academic research and scientific papers
A one-pot organometallic route from a 4-alkenylpyridine to a 4,4-spiro-linked ethyl 1,4-dihydropyridine-1-carboxylate
Fraenkel, Gideon,Chow, Albert,Liang, Yulan,Song, Jinhua,Gallucci, Judith
, p. 2063 - 2071 (2013/02/23)
In a one-pot process without isolation of intermediates, (but-3-en-1-yl)pyridine (13) is treated sequentially with dicyclohexylborane, trimethylaluminium, and ethyl carbonochloridate yielding ethyl 1,4-dihydro-4,4-(tetramethylene)pyridine-1-carboxylate (=ethyl 8-azaspiro[4.5]deca-6,9-diene-8-carboxylate; 2) in 46% yield based on starting alkenylpyridine 13 (Scheme 5). Copyright
