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377780-16-0 Usage

Chemical class

Organic compound




Heterocyclic compound


Seven-membered diazepane ring


Benzyl groups at the 1 and 4 positions

Functional group

Carboxylic acid group at the 6 position

Potential applications

Pharmaceutical (neurological disorders)

Mechanism of action

Modulation of neurotransmitter receptors

Additional use

Building block in chemical synthesis for other organic compounds

Check Digit Verification of cas no

The CAS Registry Mumber 377780-16-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,7,7,8 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 377780-16:
190 % 10 = 0
So 377780-16-0 is a valid CAS Registry Number.

377780-16-0Relevant articles and documents

Speeding up heterogeneous catalysis with an improved highly reusable catalyst for the preparation of enantioenriched secondary alcohols

Sánchez-Carnerero, Esther M.,Sandoval-Torrientes, Rafael,Urieta-Mora, Javier,Moreno, Florencio,Maroto, Beatriz L.,de la Moya, Santiago

, p. 23 - 30 (2017)

A new catalytic heterogeneous system, very efficient and highly reusable, for the preparation of enantioenriched secondary alcohols through the addition of diethylzinc to benzaldehyde has been developed. This system is based on a chiral bis(hydroxyamide) ligand supported on crosslinked polystyrene. The catalyst has been shown to be very efficient, leading to the corresponding secondary alcohol with an enantiomeric excess of 93% in a time as short as 2?h and using just 4% of the heterogeneous catalyst and just 1.5 equivalents of the organozinc reagent. We have demonstrated that the new catalyst is very stable and can be efficiently recycled with no decrease in yield or enantioselectivity. The presented system has an unquestionable interest for the potential transfer of the reaction to the industry by using catalytic fluidized-bed reactors.

Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV


, (2008/06/13)

The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that are

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