37784-17-1

Basic information

• Product Name: N-Boc-D-proline
• Synonyms: BOC-(R)-PYRROLIDINE-5-CARBOXYLIC ACID;BOC-D-PROLINE;BOC-D-PYRD(2)-OH;BOC-D-PRO-OH;BOC-D-PRO;BOC-D-PROLINE-OH;(R)-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;T-BUTYLOXYCARBONYL-D-PROLINE
• CAS NO: 37784-17-1
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.25
• EINECS: 1533716-785-6
• Product Categories: Protected Amino Acids;Pyrrole&Pyrrolidine&Pyrroline;Amino Acids;Proline [Pro, P];Boc-Amino Acids and Derivative;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series
• Mol File: 37784-17-1.mol
• Article Data: 27

Chemical Properties

• Melting Point: 134-137 °C(lit.)
• Boiling Point: 355.52°C (rough estimate)
• Flash Point: 157.7 °C
• Appearance: White to off-white/Crystalline Powder or Crystals
• Density: 1.1835 (rough estimate)
• Vapor Pressure: 2E-05mmHg at 25°C
• Refractive Index: 60 ° (C=2, AcOH)
• Storage Temp.: −20°C
• Solubility: almost transparency in Acetic acid
• PKA: 4.01±0.20(Predicted)
• BRN: 479316
• CAS DataBase Reference: N-Boc-D-proline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-D-proline(37784-17-1)
• EPA Substance Registry System: N-Boc-D-proline(37784-17-1)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 37784-17-1(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white microcrystalline powder

InChI:InChI=1/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/p-1/t7-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 344-25-2 D-Prolin 
• 124-38-9 carbon dioxide 
• 86953-79-9 tert-butyl pyrrolidine-1-carboxylate 
• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 1294505-64-8 (R)-1-tert-butyl 2-((R)-1-phenylprop-2-yn-1-yl)-pyrrolidine-1,2-dicarboxylate 
• 1294505-66-0 (R)-1-tert-butyl 2-((R)-1-(2-methoxyphenyl)prop-2-yn-1-yl)pyrrolidine-1,2-dicarboxylate 
• 73286-71-2 N-(tert-butoxycarbonyl)-2,3-dihydropyrrole 
• 350022-46-7 N-(tert-butoxycarbonyl)-2-(2-phenylethenyl)pyrrolidine 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 73365-02-3 tert-butoxycarbonyl-D-prolinal 

Downstream Products

• 141636-70-6 Boc-D-Pro-Pro-OBn 
• 140834-95-3 Boc-D-Pro-Gln-Gln-OBzl 
• 59378-81-3 1-(tert-butoxycarbonyl)prolin-2R-ol 
• 163431-77-4 (2S,4R)-1-((R)-1-tert-Butoxycarbonyl-pyrrolidine-2-carbonyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carboxylic acid benzyl ester 
• 200954-26-3 N-(tert-butoxycarbonyl)-D-prolyl-L-tyrosine methyl ester 
• 152665-79-7 (R)-tert-butyl 2-(2-diazoacetyl)pyrrolidine-1-carboxylate 
• 936025-59-1 2-{4-[4-(2,4-dichloro-benzylamino)-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carbonyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 783325-25-7 (R)-2-methylaminomethyl-1-BOC-pyrrolidine 
• 32302-76-4 H-Gly-D-Pro-D-Glu-OH 
• 853400-84-7 (S)-2-[((R)-Pyrrolidine-2-carbonyl)-amino]-pentanedioic acid dibenzyl ester 

Relevant articles and documents

RAS INHIBITORS

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Evidence and exploitation of dicationic ammonium-nitrilium superelectrophiles: direct synthesis of unsaturated piperidinones

Exploiting superacid activation, the reactivity of aminonitriles was enhanced through the transient formation of highly reactive ammonium-nitrilium superelectrophiles. Demonstrated by usingin situlow-temperature NMR experiments and confirmed by X-ray diffraction analysis, these dications can be intramolecularly trapped by non-activated alkenes to generate unsaturated piperidinones, including enantioenriched ones, in a straightforward way.

Synthesis of novel phase transfer catalysts derived from proline-mandelic acid/tartaric acid: their evaluation in enantioselective epoxidation and Darzen condensation

Abstract : Herein, we have described the synthesis of novel chiral cyclic phase transfer catalysts (PTCs). These catalysts are synthesized from proline, mandelic acid and tartaric acid by using simple synthetic methods with competitive yields. These chira