37795-93-0Relevant academic research and scientific papers
CATALYSTS FOR CHEMICAL REACTIONS IN A WATER-SURFACTANT MIXTURE
-
Page/Page column 17-19, (2018/03/26)
The present invention is directed to reaction mixtures comprising a water-surfactant mixture, wherein the catalyst comprises a compound with solubilizing groups. This technology improves the solubility of the reaction components in the water-surfactant mi
Selective amidation of unprotected amino alcohols using surfactant-in-water technology: A highly desirable alternative to reprotoxic polar aprotic solvents
Parmentier, Michael,Wagner, Mona K.,Magra, Kevin,Gallou, Fabrice
supporting information, p. 1104 - 1107 (2017/01/16)
A general selective and environmentally friendly method for the formation of amide bonds using a surfactant in water as medium is described. The use of readily available 1-ethyl-3-(3-(dimethylamino)propyl)-carbodiimide (EDC) and hydroxybenzotriazol (HOBt)
Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture
Conte, Immacolata,Giuliano, Claudio,Ercolani, Caterina,Narjes, Frank,Koch, Uwe,Rowley, Michael,Altamura, Sergio,Francesco, Raffaele De,Neddermann, Petra,Migliaccio, Giovanni,Stansfield, Ian
scheme or table, p. 1779 - 1783 (2009/12/03)
The RNA replication machinery of HCV is a multi-subunit membrane-associated complex. NS5A has emerged as an active component of HCV replicase, possibly involved in regulation of viral replication and resistance to the antiviral effect of interferon. We report here substituted piperazinyl-N-(aryl)benzamides as potent inhibitors of HCV replication exerted via modulation of the dimerization of NS5A.
MODULATORS OF HCV REPLICATION
-
Page/Page column 17; 28, (2008/06/13)
The present invention is directed to the use of compounds of formula (I): 1 R X 3 R Y ( I) 2 R 5 where X, Y, R1, R2 and R3 are defined therein, which can act as modulators of viral replication and/or virus production, especially of the hepatitis C virus (HCV), in a cell based system.
