3780-59-4Relevant academic research and scientific papers
Carbonyl homologation via α-trimethylsilyl β-lactone rearrangements. A nonbasic alternative to the Wittig reaction
Black,Zhang,Huang,Smith,Yates
, p. 15 - 20 (2007/10/02)
Saturated and unsaturated aldehydes and ketones, when treated with trimethylsilylketene and BF3 for 16 hours, form β-lactones which spontaneously rearrange to α,β-unsaturated TMS esters; these hydrolyze during workup to form the corresponding carboxylic acids.
