37801-53-9

Upstream product

• 37801-52-8 1-butyl-4-chloro-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 3524-35-4 1-butyl-3-methyl-1H-pyrazol-5-amine 
• 37799-83-0 2-[(2-butyl-5-methyl-2H-pyrazol-3-ylamino)-methylene]-malonic acid diethyl ester 

Downstream Products

• 1026030-61-4 1-butyl-4-chloro-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride 

Relevant academic research and scientific papers

Discovery of new orally active phosphodiesterase (PDE4) inhibitors

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.