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Biological Activity

Antagonist at the mGlu 5 receptor (K i = 295 nM). Inhibits human mGlu 5 receptor-mediated calcium flux with an IC 50 of 134 nM.

Check Digit Verification of cas no

The CAS Registry Mumber 37804-11-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,8,0 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 37804-11:
(7*3)+(6*7)+(5*8)+(4*0)+(3*4)+(2*1)+(1*1)=118
118 % 10 = 8
So 37804-11-8 is a valid CAS Registry Number.

InChI:InChI=1/C12H13ClN6O.ClH/c1-19(2)11-9(13)17-8(10(14)18-11)12(20)16-7-4-3-5-15-6-7;/h3-6H,1-2H3,(H2,14,18)(H,16,20);1H

37804-11-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	3-amino-6-chloro-5-(dimethylamino)-N-pyridin-3-ylpyrazine-2-carboxamide,hydrochloride

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:37804-11-8 SDS

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37804-11-8Relevant academic research and scientific papers

BIPYRIDYL AMIDES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5

-

Page/Page column 47, (2008/06/13)

The present invention is directed to novel amides such as those of Formula (I): (I) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood

Dipyridyl amides: Potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists

Bonnefous, Celine,Vernier, Jean-Michel,Hutchinson, John H.,Chung, Janice,Reyes-Manalo, Grace,Kamenecka, Theodore

, p. 1197 - 1200 (2007/10/03)

The mGlu5 receptor has been implicated in a number of CNS disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amides as small molecules mGluR5 antagonists.

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