37804-11-8 Usage
Biological Activity
Antagonist at the mGlu 5 receptor (K i = 295 nM). Inhibits human mGlu 5 receptor-mediated calcium flux with an IC 50 of 134 nM.
Check Digit Verification of cas no
The CAS Registry Mumber 37804-11-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,8,0 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 37804-11:
(7*3)+(6*7)+(5*8)+(4*0)+(3*4)+(2*1)+(1*1)=118
118 % 10 = 8
So 37804-11-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H13ClN6O.ClH/c1-19(2)11-9(13)17-8(10(14)18-11)12(20)16-7-4-3-5-15-6-7;/h3-6H,1-2H3,(H2,14,18)(H,16,20);1H
37804-11-8Relevant articles and documents
BIPYRIDYL AMIDES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5
-
Page/Page column 47, (2008/06/13)
The present invention is directed to novel amides such as those of Formula (I): (I) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood