37805-86-0

Usage

Uses

Used in Medicinal Chemistry:
2',3',5'-Tri-O-benzoyl-5-Methoxyuridine is used as a key intermediate in the synthesis of antiviral and anticancer drugs due to its enhanced lipophilicity and stability. Its unique chemical properties allow for the development of more effective pharmaceutical agents targeting various diseases.
Used in Nucleic Acid Research:
In the field of nucleic acid research, 2',3',5'-Tri-O-benzoyl-5-Methoxyuridine is used as a building block for the synthesis of modified RNA sequences. These modified sequences can be employed in various studies and applications, such as understanding the structure and function of RNA molecules, developing RNA-based therapeutics, and exploring the potential of RNA interference.
Used in Pharmaceutical Research:
2',3',5'-Tri-O-benzoyl-5-Methoxyuridine is utilized in pharmaceutical research to investigate its potential pharmacological uses. Its unique chemical structure and properties make it an important compound for exploring new drug targets and developing innovative therapeutic strategies.
Used in Drug Delivery Systems:
In drug delivery systems, 2',3',5'-Tri-O-benzoyl-5-Methoxyuridine can be employed as a component of carriers for targeted drug delivery. Its enhanced lipophilicity allows for improved solubility and bioavailability, leading to more effective therapeutic outcomes.
Used in Biochemistry Research:
2',3',5'-Tri-O-benzoyl-5-Methoxyuridine is also used in biochemistry research to study the interactions between nucleic acids and other biomolecules. Its unique chemical properties provide insights into the mechanisms of nucleic acid function and regulation, contributing to a deeper understanding of biological processes.

Upstream product

• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 6623-81-0 5-methoxyuracil 
• 14215-97-5 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose 
• 22224-38-0 1,2,3,5-tetra-O-benzoyl-β-D-ribofuranose 
• 37805-85-9 5-methoxy-2,4-bis-trimethylsilanyloxy-pyrimidine 

Downstream Products

• 1613530-29-2 C₃₃H₂₇N₅O₉ 
• 1613530-30-5 C₃₁H₂₇N₃O₉ 
• 35542-01-9 5-methoxycarbonylmethyl-2'-O-methyl-uridine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists

P2Y6 receptor (P2Y6-R) is involved in various physiological and pathophysiological events. With a view to set rules for the design of UDP-based reversible P2Y6-R antagonists as potential drugs, we established structure-activity relationship of UDP analogues, bearing modifications at the uracil ring, ribose moiety, and the phosphate chain. For instance, C5-phenyl- or 3-NMe-uridine-5′-α,β-methylene-diphosphonate, 16 and 23, or lack of 2′-OH, in 12-15, resulted in loss of both agonist and antagonist activity toward hP2Y6-R. However, uridylyl phosphosulfate, 19, selectively inhibited hP2Y6-R (IC50 112 μM) versus P2Y2/4-Rs. In summary, we have established a comprehensive SAR for hP2Y6-R ligands towards the development of hP2Y6-R antagonists.

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.

Nucleoside Syntheses, XXV. A New Simplified Nucleoside Synthesis

The several steps of the Friedel-Crafts catalyzed silyl-Hilbert-Johnson nucleoside synthesis - silylation of the heterocyclic base, silylation of the perfluorosulfonic acids or its salts (if SnCl4 is not used as catalyst) and finally the nucleoside synthesis itself - can be combined to a simple one-step/one-pot reaction which generally affords nucleosides in high yields.

Nucleoside Syntheses, XXII. Nucleoside Synthesis with Trimethylsilyl Triflate and Perchlorate as Catalysts

The novel Lewis acids (CH3)3SiOSO2CF3 (5), (CH3)3SiOSO2C4F9 (6), and (CH3)3SiClO4 (4) are highly selective and efficient Friedel-Crafts catalysts for nucleoside formation from silylated heterocycles and peracylated sugars as well as for rearrangements of persilylated protected nucleosides.With basic silylated heterocycles these new catalysts give much higher yields of the natural N-1-nucleosides than with SnCl4.