37829-66-6Relevant academic research and scientific papers
Dibenzo-fused seven-membered nitrogen heterocycles by a tandem reduction-lactamization reaction
Bunce, Richard A.,Schammerhorn, James E.
, p. 1031 - 1035 (2007/10/03)
Efficient syntheses of dibenz[b,f][1,4]oxazepin-11(10H)-one, 5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one and 5,11-dihydro-6H-dibenz[b, e]azepin-6-one are described using a tandem reduction-lactamization sequence. Precursors for these ring systems are available in 1-3 steps using nucleophilic aromatic substitution and Ullmann coupling methodology. Direct reduction-lactamization of these compounds using iron powder in acetic acid at 115° affords the target heterocycles in ≥90% yield.
