3784-30-3

Basic information

• Product Name: 5-(2-AMinopropyl)indole
• Synonyms: 5-(2-AMinopropyl)indole;5-IT;5-AMinopropylindole;1H-Indole-5-ethanaMine, α-Methyl-;5-API (5-IT) solution;1-(1H-indol-5-yl)propan-2-amine
• CAS NO: 3784-30-3
• Molecular Formula: C₁₁H₁₄N₂
• Molecular Weight: 174.24226
• Product Categories: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 3784-30-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 344.524 °C at 760 mmHg
• Flash Point: 2℃
• Appearance: /
• Density: 1.122 g/cm³
• Storage Temp.: -20°C
• PKA: 17.13±0.30(Predicted)
• CAS DataBase Reference: 5-(2-AMinopropyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-AMinopropyl)indole(3784-30-3)
• EPA Substance Registry System: 5-(2-AMinopropyl)indole(3784-30-3)

Safety Data

• RIDADR: UN 1648 3 / PGII
• WGK Germany: 2
• Hazardous Substances Data: 3784-30-3(Hazardous Substances Data)

Usage

Description

5-IT is a positional isomer of α-methyltryptamine ; α-methyltryptamine is a psychedelic drug that is regulated in the United States. 5-IT has been associated with recent deaths. This product is intended for research and forensic applications.

Uses

5-Aminopropylindole is a 5-substituted indole analogue and positional isomer of the psychedelic drug α-Methyltryptamine (M331925).

Synthetic route

5‐(2‐aminopropyl)indol (3784-30-3) → 5‐(2‐aminopropyl)indol + 5‐(2‐aminopropyl)indol

Conditions	Yield
With (2R,3R,11R,12R)-(+)-18-crown-6-2,3,11,12-tetracarbonic acid In aq. buffer at 20℃; for 0.25h; pH=2.1; Resolution of racemate; enantioselective reaction;
With Lux i-Amylose-1 column In hexane; diethylamine; isopropyl alcohol at 20℃; Resolution of racemate;

5‐(2‐aminopropyl)indol (3784-30-3) → C11H14N2 + C11H14N2

Conditions	Yield
With β‐cyclodextrin In aq. phosphate buffer at 25℃; pH=2.5; Reagent/catalyst; Resolution of racemate;