3784-89-2 Usage
Originator
Trophenium ,American Cyanamid (AHP), US ,1961
Manufacturing Process
330 g (1.2 M) of homatropine were dissolved in 1 liter of dry methyl ethyl ketone and gently refluxed on a water-bath during the gradual addition of a solution of 204 g (1.32 M) redistilled phenacyl chloride in 200 ml of the same solvent. After 10 to 15 minutes 1 g of previously prepared homatropine phenacyl chloride was added to avoid formation of a supersaturated solution of the quaternary compound. Reflux was continued for 9 hours, then the thick suspension was allowed to cool, filtered and washed with 200 ml methyl ethyl ketone to yield 490 g (95%) slightly creamy solid, MP 188°C to 191°C.For purification the crude quaternary salt was dissolved in hot ethyl alcohol (2 ml/g) and warm dry acetone (8 ml/g) was stirred into the clear filtrate. On cooling, 387 g (78 % recovery) of a pure white powder, MP 195°C to 197°C, were obtained, in which the ionizable chlorine assayed at 99.7% of the theoretical value.
Therapeutic Function
Antihypertensive
Check Digit Verification of cas no
The CAS Registry Mumber 3784-89-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,8 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3784-89:
(6*3)+(5*7)+(4*8)+(3*4)+(2*8)+(1*9)=122
122 % 10 = 2
So 3784-89-2 is a valid CAS Registry Number.
InChI:InChI=1/C24H28NO4.ClH/c1-25(16-22(26)17-8-4-2-5-9-17)19-12-13-20(25)15-21(14-19)29-24(28)23(27)18-10-6-3-7-11-18;/h2-11,19-21,23,27H,12-16H2,1H3;1H/q+1;/p-1
