3786-88-7Relevant academic research and scientific papers
Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin
Lown, J. William,Krowicki, Krzysztof
, p. 3774 - 3779 (2007/10/02)
New and efficient total syntheses of the natural oligopeptide antiviral antibiotics netropsin and distamycin are described.These procedures feature a different strategy of introduction of the terminal groups from that used hitherto, high yield coupling steps, improvements in the Pinner reaction for introducing the amidine moiety, and the novel use of N-formylimidazole for introduction of the formyl moiety in distamycin.The methods also avoid column chromatography with the attendant contamination of the oligopeptide hydrochlorides with inorganic salts eluted from adsorbents.The synthetic procedures are general and may be adapted to the synthesis of related oligopeptide structures.
Structure-Activity Relationships of Pyrrole Amidine Antiviral Antibiotics. 2. Preparation of Mono- and Tripyrrole Derivatives of Congocidine
Bialer, Meir,Yagen, Boris,Mechoulam, Raphael,Becker, Yechiel
, p. 1144 - 1148 (2007/10/02)
Representatives of three types of congocidine (1) analogues were synthesized.These were tested for cytotoxicity, inhibition of herpes simplex virus (HSV) replication in cultured cells, and effects on the synthesis of HSV DNA in isolation nuclei in vitro, as well as on DNA synthesis by purified HSV-DNA polymerase.All synthesized tripyrrole derivatives of congocidine were less cytotoxic and more active than the parent drug in all the three antiviral tests.
