37864-85-0

Basic information

• Product Name: 3-methyl-5-(methylsulfonyl)-1,2,4-thiadiazole
• CAS NO: 37864-85-0
• Molecular Formula: C₄H₆N₂O₂S₂
• Molecular Weight: 178.2326
• Mol File: 37864-85-0.mol

Chemical Properties

• Boiling Point: 334.4°C at 760 mmHg
• Flash Point: 156°C
• Density: 1.444g/cm³
• Vapor Pressure: 0.000249mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 3-methyl-5-(methylsulfonyl)-1,2,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-5-(methylsulfonyl)-1,2,4-thiadiazole(37864-85-0)
• EPA Substance Registry System: 3-methyl-5-(methylsulfonyl)-1,2,4-thiadiazole(37864-85-0)

Safety Data

• Hazardous Substances Data: 37864-85-0(Hazardous Substances Data)

Upstream product

• 21734-85-0 5-chloro-3-methyl-1,2,4-thiazole 
• 20277-69-4 sodium methansulfinate 

Relevant articles and documents

1,2,4- THIADIAZOL-5-THIO COMPOUNDS AND THE DERIVATIVES THEREOF, METHODS FOR THE PRODUCTION THEREOF AND USE THEREOF AS UREASE AND NITRIFICATION INHIBITORS

The invention relates to methods for the production and use of novel 1,2,4-thiadiazols of general formulae (I) or (II) as agents for regulating the inhibition of enzymatic urea hydrolysis, wherein R1 = hydrogen, C1-C8-alkyl or C6-C10-aryl and R2 = hydrogen, C1-C8- alkyl/heteroalkyl, C2-C8 -alkenyl/heteroalkenyl, C2-C8 -alkinyl/heteroalkinyl, C3-C8- cycloalkyl/heterocycloalkyl, C3-C8 -cycloalkenyl/heterocycloalkenyl, C6-C10 -aryl/heteroaryl, aralkyl, heteroarylalkyl, alkaryl, akheteroaryl, alkoxy, aryloxy, hetaryloxy, alkylthio, arylthio, hetarylthio, acyl, aroyl, hetaroyl, acyloxy, aroyloxy, hetaroyloxy, alkoxycarbonyl, aryloxycarbonyl, hetaryloxycarbonyl, amino, alkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, fluorine, chlorine, bromine, iodine, hydroxy, cyano, nitro, sulfo, carbonyl, carboxy, carbamoyl, sulfamoyl, the radicals R1 and/or R2 can, optionally, be per se and individually substituted by one or several of the above-mentioned groups. With a limited spectrum of substituents in R2, said compounds can be claimed as nitrification inhibitors. The inventive 1,2,4-thiadiazols thus used are effective urease inhibitors and have a good resistance to hydrolysis and can be produced according to known methods. They are also effective nitrification inhibitors and can delay transformation of ammonia. They are the first inhibitors which effectively eliminate the two main sources of loss during the application of manure, i.e. urease-catalyzed urea hydrolysis and nitrification of ammonia nitrogen. The inventive compounds can also be combined with more potent nitrification inhibitors, whereby nitrogen losses can also be reduced, without any problem.