37867-38-2Relevant academic research and scientific papers
AlCl3-promoted cyclization of β-keto derivatives with in situ generated enamines under solvent-free high speed ball milling: An efficient one-pot access to polysubstituted 1,4-dihydropyridines
Zeng, Ji-Chao,Yu, Fei,Asiri, Abdullah M.,Marwani, Hadi M.,Zhanga, Ze
, p. 2054 - 2064 (2017/11/21)
Under high speed ball milling (HSBM), a simple method for efficient synthesis of structurally diverse polysubstituted 1,4-dihydropyridines is developed via AlCl3-promoted Robinson-like cyclization of β-keto derivatives with in situ generated enamines. This one-pot protocol exhibits the advantages of high chemoselectivity, short reaction time, good functional group tolerance, mild reaction condition and easy work-up.
