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Usage

Uses

Used in Medical Research:
HUMAN IL-8 is used as a research tool for studying neutrophil chemotaxis, which is the process by which neutrophils move towards the site of infection or inflammation in response to a chemical gradient. Understanding the role of IL-8 in this process can help researchers develop new therapeutic strategies for treating various inflammatory and immune-related disorders.
Used in Cellular Biology:
HUMAN IL-8 is used as a research tool for studying the uptake of apoptotic cells by meningothelial cells. Apoptosis, or programmed cell death, is a crucial process in maintaining tissue homeostasis and preventing the accumulation of damaged or infected cells. By investigating the role of IL-8 in this process, researchers can gain insights into the mechanisms underlying tissue repair and immune regulation.
Used in Endothelial Cell Function Studies:
HUMAN IL-8 is used as a research tool for studying the effect of IL-8 on the expression and secretion of urocortin-1 by human umbilical vein endothelial cells. Urocortin-1 is a neuropeptide that has been implicated in various physiological processes, including stress response, immune regulation, and vascular function. Understanding the interaction between IL-8 and urocortin-1 can provide valuable information on the complex interplay between the immune system and the vascular endothelium, which may have implications for the development of novel therapeutic approaches for various vascular and immune-related diseases.

Biochem/physiol Actions

Interleukin-8 (IL-8) was formerly called monocyte-derived neutrophil chemotactic factor. It belongs to the chemokine α or C-X-C family. Like other members of this family, the mature form of IL-8 has four cysteine residues and the first two cysteine residues are separated by glutamine. IL-8 shows chemotactic activity in vitro for T cells, neutrophils and basophils. Mutation in IL-8 can increase risk to acute pancreatitis.