378773-52-5Relevant academic research and scientific papers
One-pot three-component synthesis of 4(3 H)-quinazolinones from benzyl halides, isatoic anhydride, and primary amines
Adib, Mehdi,Sheikhi, Ehsan,Bijanzadeh, Hamid Reza
, p. 85 - 88 (2012/02/04)
A novel, one-pot, and three-component synthesis of 4(3H)-quinazolinones is described. Benzyl halides are oxidized to aldehydes under mild Kornblum conditions then undergo a three-component reaction with isatoic anhydride and primary amines to produce 4(3H)-quinazolinones in excellent yields. Georg Thieme Verlag Stuttgart. New York.
A practical and versatile approach toward a one-pot synthesis of 2,3-disubstituted 4(3H)-quinazolinones
Dabiri, Minoo,Salehi, Peyman,Bahramnejad, Mahboobeh,Alizadeh, Mohsen
experimental part, p. 877 - 881 (2011/06/26)
An effective one-pot three-component route to 4(3H)-quinazolinones from commercially available starting materials is reported. Thus, isatoic anhydride reacted with ammonium acetate or primary amines and aldehydes in the presence of iodine to produce the corresponding quinazolinone derivatives in moderate to good yields. Springer-Verlag 2010.
Palladium-catalyzed cyclocarbonylation of o-lodoanilines with Imidoyl Chlorides to produce quinazolin-4(3H)-ones
Zheng, Zhaoyan,Alper, Howard
supporting information; experimental part, p. 829 - 832 (2009/04/07)
A wide variety of substituted quinazolin-4(3H)-ones were prepared in 63-91% yields by the palladium-catalyzed cyclocarbonylation of o-iodoanilines with imidoyl chlorides and carbon monoxide. The reaction is believed to proceed via in situ formation of an amidine, followed by oxidative addition, CO insertion, and intramolecular cyclization to give the substituted quinazolin-4(3H)-ones.
