37896-11-0

Upstream product

• 7386-21-2 N-(4-chlorophenyl)phthalimide 
• 85-44-9 phthalic anhydride 
• 106-47-8 4-chloro-aniline 
• 7142-94-1 N-(4-chlorophenyl)phthalamic acid 
• 109949-64-6 2-(4-chlorophenyl)-2,3-dihydro-1H-isoindole 
• 91-13-4 α,α'-dibromo-o-xylene 

Downstream Products

• 88460-54-2 2,3-Dihydro-3-oxo-2-(p-chlorophenyl)-1H-isoindole-1-acetic Acid 
• 132868-75-8 2,3-Dihydro-3-oxo-2-(p-chlorophenyl)-1H-isoindole-1-acetyl Chloride 
• 1159500-08-9 C₂₄H₁₆ClNO₂ 
• 1583289-23-9 3-{1-[6-chloro-3-(4-chlorophenyl)-1H-inden-2-yl]-2-methylprop-1-en-1-yl}-2-(4-chlorophenyl)isoindolin-1-one 

Relevant academic research and scientific papers

Oxidative Desymmetrization of Isoindolines Realized by tert -Butyl Nitrite (TBN) Initiated Radical sp 3C-H Activation Relay (CHAR)

An oxidative desymmetrization of isoindolines was realized by TBN initiated radical sp 3C-H activation relay (CHAR), providing a series of ω-hydroxylactams in high yields. This reaction exhibits broad substrate scope and functional group tolerance, and even N -alkyl iso-indolines can be well tolerated. The mechanistic study shows that the C-H bond oxidation, dioxygen trapping and intramolecular 1,5-H shift might be the key steps to achieve the oxidative desymmetrization.

Preparation method of hydroxyl lactam

The invention discloses a preparation method of hydroxyl lactam. The hydroxyl lactam is prepared from cyclic imide shown in a formula (II) through a homogeneous catalytic hydrogenation reaction, wherein R1, R2 and R3 are respectively and independently H,

Br?nsted acid mediated intramolecular cyclopropane ring expansion/[4 + 2]-cycloaddition

A cascade reaction of 3-hydroxy-2-phenylisoindolin-1-one and cyclopropyl ketone has been developed via a Br?nsted acid-promoted ring-opening/intramolecular cross-cycloaddition/[4 + 2]-cycloaddition process. The developed methodology provides straightforward access to pentacyclic isoindolin-1-one derivatives under simple reaction conditions.

Aza-DielsAlder reaction between N-aryl-1-oxo-1H-isoindolium ions and tert-enamides: Steric effects on reaction outcome

The synthesis of 5-substituted 6,6a-dihydroisoindolo[2,1-a]quinolin-11(5H)- ones via [4 + 2] imino-DielsAlder cyclization from N-aryl-3- hydroxyisoindolinones and N-vinyl lactams under Lewis acid-catalysed anhydrous conditions is reported. Reactions of N-(2-substituted-aryl)-3- hydroxyisoindolinones with N-vinylpyrrolidone under identical conditions resulted in the formation of 2-(2-substitued-aryl)-3-(2-(2-oxopyrrolidin-1-yl) vinyl)isoindolin-1-one analogues indicating steric hinderance as the cause of deviation. The probable mechanism of the reaction based on the results from X-ray crystallography and molecular modelling is discussed.

Stereoselective cycloaddition of N-acyliminium ions with α,β-unsaturated ketones and esters

The [4+2] reactions of N-acyliminium ions, produced from 2-aryl-3-hydroxy-2,3-dihydroisoindol-1-onesor5-hydroxy-1-phenyl-2,5-dihydro/2,3,4,5-tetrahydropyrrol-2-ones in the presence of BF3OEt2, with α,β-unsaturated ketones or esters w

Efficient synthesis of aryl hydroxylactams by reducing imides with activated zinc dust

A series of aryl hydroxylactams (2a, 2b, 2d-2g, 2i-2k, 2m, and 2n) was synthesized by partially reducing aryl cyclic imides in moderate to excellent yields with activated zinc dust alone in acetic acid. This method was regiospecific and can be employed as an alternative for reported methods to partially reduce aryl cyclic imides. Copyright Taylor & Francis Group, LLC.