3790-52-1 Usage
Uses
Used in Pharmaceutical Research:
H-ASP(GLY-OH)-OH is used as a research compound for studying the enzymatic reactions involving glycosylasparaginase, an enzyme that plays a crucial role in the metabolism of certain peptides. Understanding these reactions can provide insights into the development of new drugs and therapies for various diseases.
Used in Chemical Synthesis:
In the field of chemical synthesis, H-ASP(GLY-OH)-OH can be used as a building block for the creation of more complex peptide structures. Its dipeptide nature allows for further modification and incorporation into larger molecules, which can have potential applications in drug development and other chemical processes.
Used in Analytical Chemistry:
H-ASP(GLY-OH)-OH can also be employed as a reference compound in analytical chemistry, particularly in the development and validation of methods for the analysis of peptides and proteins. Its well-defined structure and properties make it a suitable candidate for calibration and quality control purposes.
Used in Biochemical Education:
In the context of biochemical education, H-ASP(GLY-OH)-OH can serve as a model compound for teaching students about peptide bond formation, enzymatic reactions, and the role of amino acids in biological systems. Its simplicity and relevance to various biological processes make it an ideal tool for educational purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 3790-52-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,9 and 0 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3790-52:
(6*3)+(5*7)+(4*9)+(3*0)+(2*5)+(1*2)=101
101 % 10 = 1
So 3790-52-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H10N2O5/c7-3(6(12)13)1-4(9)8-2-5(10)11/h3H,1-2,7H2,(H,8,9)(H,10,11)(H,12,13)
3790-52-1Relevant academic research and scientific papers
A Quantitative Evaluation of Methods for Coupling Asparagine
Mojsov, Svetlana,Mitchell, Alexander R.,Merrifield, R. B.
, p. 555 - 560 (2007/10/02)
A quantitative procedure was developed to evaluate methods for coupling asparagine.Boc-asparagine was coupled to glycyloxymethylphenoxymethyl-copoly(styrene-divinylbenzene) resin under a variety of conditions, and the product, Asn-Gly, and any byproducts were cleaved from the resin with 50percent trifluoroacetic acid in methylene chloride.The mixture was then separated on a sulfonated ion exchange column and quantitated by the ninhydrin reaction.Coupling by the dicyclohexylcarbodiimide (DCC) or symmetrical anhydride methods gave large amounts of the dehydration product, β-cyanoalanylglycine, and smaller amounts of β-aspartamidinoacetic acid, α-aspartylglycine, and β-aspartylglycine in addition to the desired asparaginylglycine.Activation of Boc-Asn by DCC plus hydroxybenzotriazole or by the nitrophenyl ester gave 98 to 99percent of Asn-Gly, but very low levels of the byproducts were detectable with the sensitive chromatographic method.Protection of the amide function of Boc-Asn with the 4,4'-dimethoxybenzhydryl group avoided completely the formation of the nitrile during DCC coupling.Pure Ala(CN)-Gly was quantitatively reconverted to Asn-Gly by HF.The rehydration of nitrile also occurred in 50percent trifluoroacetic acid in dichloromethane, but much more slowly.
