37910-80-8Relevant academic research and scientific papers
N-substituted-imidazoles as inhibitors of nitric oxide synthase: A preliminary screening
Salerno,Sorrenti,Guerrera,Sarva,Siracusa,Di Giacomo,Vanella
, p. 685 - 690 (2007/10/03)
Identification of potent and selective inhibitors of inducible or neuronat nitric oxide synthase (NOS) is of great interest because of their therapeutic potential for treatment of diseases mediated by overproduction of nitric oxide. Imidazole derivatives
Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(ω-phenyl-ω-hydroxyalkyl)imidazoles
Nardi,Tajana,Leonardi,Pennini,Portioli,Magistretti,Subissi
, p. 727 - 731 (2007/10/02)
A novel series of N-(benzoylalkyl)imidazoles and N-(ω-phenyl-ω-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[β-[4-(β-phenylethyl)phenyl]-β-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.
