37918-84-6Relevant academic research and scientific papers
Intermolecular Hydroamination of 1,3-Dienes to Generate Homoallylic Amines
Yang, Xiao-Hui,Lu, Alexander,Dong, Vy M.
, p. 14049 - 14052 (2017)
We report a Rh-catalyzed hydroamination of 1,3-dienes to generate homoallylic amines. Our work showcases the first case of anti-Markovnikov selectivity in the intermolecular coupling of amines and 1,3-dienes. By tuning the ligand properties and Br?nsted acid additive, we find that a combination of rac-BINAP and mandelic acid is critical for achieving anti-Markovnikov selectivity.
Visible-light photoredox-promoted desilylative allylation of α-silylamines: An efficient route to synthesis of homoallylic amines
Cheng, Fukun,Fan, Lulu,Liu, Guoxing,Mao, Pu,Yuan, Jinwei,Zhang, Tingting
supporting information, (2021/09/08)
A facile and efficient synthesis of homoallylic amines by visible-light photoredox-promoted desilylative allylation of α-silylamines with allylic sulfones is described. A variety of α-silylamines derived from anilines, cyclic and acyclic alkyl amines reacted with a serious of mono or disubstituted allylic sulfones well to provide homollylic amines in good to high yields under very mild reaction conditions.
