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Usage

Benzoic acid hydrazide derivative

The compound is derived from benzoic acid by attaching a hydrazide group, which is a key feature in its chemical structure and reactivity.

4-chloro-benzyloxy group

The compound contains a 4-chloro-benzyloxy group, which is a chlorine atom attached to a benzyl group that is connected to an oxygen atom. This group influences the compound's properties and potential applications.

Organic synthesis and pharmaceutical research

2-(4-chloro-benzyloxy)-benzoic acid hydrazide is commonly used in the synthesis of other organic compounds and in the development of new pharmaceuticals.

Potential drug development

The compound has potential applications in the development of new drugs and pharmaceuticals due to its unique structure and properties.

Medicinal chemistry and drug discovery

Researchers in the fields of medicinal chemistry and drug discovery find 2-(4-chloro-benzyloxy)-benzoic acid hydrazide to be a valuable tool for their studies and experiments.

Unique structure and properties

The compound's structure and properties make it distinct from other related compounds, which contributes to its value in research and potential applications.

Upstream product

• 119-36-8 methyl salicylate 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Relevant academic research and scientific papers

Target β-catenin/CD44/Nanog axis in colon cancer cells by certain N′-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides

Cell surface molecule CD44 plays a major role in regulation of cancer stem cells CSCs on both phenotypic and functional level, however chemical inhibition approach of CD44 to targets CSCs is poorly studied. Herein, we report the discovery of certain N′-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides as a novel inhibitor of CD44. Molecular docking study showed interference of the scaffold of these compounds with β-catenin/TCF-4 complex, building a direct relationship between CD44 inhibition and observed well-fitted binding domain. Compound 11a, most potent member elicits inhibition effect on TCF/LEF reporter activity conformed the involvement of Wnt pathway inhibition as a mechanism of action. Furthermore, the treatment by the mentioned compound leads to inhibition of embryonic transcriptional factor Nanog but not Sox2 or Oct-4 suggested specific targeted effect. Moreover, the cytotoxicity and cell cycle effect of this series seems to be dependent on CD44 expression.

Synthesis and anticonvulsant activity of new 2-substituted-5-(2- benzyloxyphenyl)-1,3,4-oxadiazoles

A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism.