37932-44-8

Upstream product

• 76226-60-3 (3-chlorophenyl)-morpholino-methanethione 
• 766-84-7 3-chloro-benzonitrile 

Downstream Products

• 86997-17-3 2,5-bis(3-chlorophenyl)-7-methyl-7-(1-methylcycloprop-2-enyl)-3,4-diazbicyclo[4.1.0]hepta-2,4-diene 
• 86997-17-3 (1S,6R,7S)-2,5-Bis-(3-chloro-phenyl)-7-methyl-7-(1-methyl-cycloprop-2-enyl)-3,4-diaza-bicyclo[4.1.0]hepta-2,4-diene 
• 87038-56-0 (1S,6R,7R)-2,5-Bis-(3-chloro-phenyl)-7-methyl-7-[2-(1-methyl-cyclopropyl)-ethyl]-3,4-diaza-bicyclo[4.1.0]hepta-2,4-diene 
• 86997-24-2 (1S,6R,7S)-2,5-Bis-(3-chloro-phenyl)-7-methyl-7-[2-(1-methyl-cyclopropyl)-ethyl]-3,4-diaza-bicyclo[4.1.0]hepta-2,4-diene 
• 86997-12-8 3,7-bis(3-chlorophenyl)-1,5-dimethylsemibullvalene 

Relevant academic research and scientific papers

Synthesis and antitumor activity of s-tetrazine derivatives

Fifty-five compounds of s-tetrazine derivative including hexahydro-, 1,6-dihydro, 1,4-dihydro-, 1,2-dihydro- and aromatic s-tetrazine were prepared. Their antitumor activities were evaluated in vitro by MTT method for P-388 cell and SRB method for A-549 cell. The results show that there are 9 compounds which in 10-6 μM have more than 50% inhibition rate to A-549 cancer cell growth, and 7 compounds in 10-6 μM have more than 50% inhibition rate to P-388 cancer cell growth. The IC50 of compound 3q for P-388, Bel-7402, MCF-7 and A-549 are 0.6 μM, 0.6 μM, 0.5 μM and 0. 7 μM, respectively. So s-tetrazine derivative is a kind of compound which possesses potential antitumor activities and is worth to research further.

BADANIA W DZIEDZINIE TIOAMIDOW I ICH POCHODNYCH IX. SYNTEZA POCHODNYCH 1,2,4,5-TETRAZYNY

In reactions of N,N-disubstituted thioamides, derivatives of 4-thiobenzoylmorpholine, 1-thiobenzoylpiperidine and N1,N2-di(α-morpholinobenzylidene)azine, N1,N2-di(α-piperidinobenzylidene)azine also 4-(R-α-phenylaminobenzylidene)morpholinium and 1-(R-α-phenylaminobenzylidene)piperidinium iodides with hydrazine there was obtained a series compounds, derivatives of 1,2,4,5-tetrazine.Structures of obtained compounds have been determined by elemental analysis and on the ground of their UV and IR spectra.