3794-83-0

Basic information

• Product Name: (1-Hydroxyethylidene)bis-phosphonic acid tetrasodium salt
• Synonyms: (1-hydroxyethylidene)-diphosphonicacitetrasodiumsalt;1-Hydroxyethylidene-1,1-diphosphonicacid,tetrasodiumsalt;deflocen43;dequest2016;ethane-1-hydroxy-1,1-diphosphonicacid,tetrasodiumsalt;Phosphonicacid,(1-hydroxyethylidene)bis-,tetrasodiumsalt;sequion10na4;tarpinel4nl
• CAS NO: 3794-83-0
• Molecular Formula: C₂H₄O₇P₂*4Na
• Molecular Weight: 293.96
• EINECS: 223-267-7
• Product Categories: Phosphonate antiscalant
• Mol File: 3794-83-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 578.8 °C at 760 mmHg
• Flash Point: 303.8 °C
• Appearance: Brown viscous liquid
• Density: 2.074[at 20℃]
• Vapor Pressure: 0Pa at 25℃
• PKA: 2.18[at 20 ℃]
• Water Solubility: 774g/L at 20℃
• CAS DataBase Reference: (1-Hydroxyethylidene)bis-phosphonic acid tetrasodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Hydroxyethylidene)bis-phosphonic acid tetrasodium salt(3794-83-0)
• EPA Substance Registry System: (1-Hydroxyethylidene)bis-phosphonic acid tetrasodium salt(3794-83-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/38-36-22
• Safety Statements: 26-36/37/39-36
• RTECS: JL6475000
• Hazardous Substances Data: 3794-83-0(Hazardous Substances Data)

Usage

Uses

(1-Hydroxyethylidene)bis-phosphonic Acid Tetrasodium Salt is used in method for applying a gel compound on a surface of a device and corresponding coated device.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C2H8O7P2.4Na/c1-2(3,10(4,5)6)11(7,8)9;;;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;;;/q;4*+1

Upstream product

• 30148-50-6 bis(trimethylsilyl)phosphonite 
• 6838-42-2 acetylphosphonic acid di(trimethylsilyl) ester 
• 75-36-5 acetyl chloride 
• 64-19-7 acetic acid 
• 2809-21-4 1-hydroxyethylene-(1,1-diphosphonic acid) 
• 141-43-5 ethanolamine 
• 106-89-8 epichlorohydrin 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 

Downstream Products

• 34162-79-3 vinylidene-1,1-diphosphonic acid 

Relevant articles and documents

One-pot synthesis of phosphinylphosphonate derivatives and their anti-tumor evaluations

This paper reports on the synthesis of new hydroxymethylene-(phosphinyl)phosphonates (HMPPs). A methodology has been developed to propose an optimized one-pot procedure without any intermediate purifications. Various aliphatic and (hetero)aromatic HMPPs were synthesized in good to excellent yields (53–98%) and the influence of electron withdrawing/donating group substitution on aromatic substrates was studied. In addition, the one-pot synthesis of HMPP was monitored by31P NMR spectroscopy, allowing effective control of the end of the reaction and identification of all phosphorylated intermediate species, which enabled us to propose a reaction mechanism. Optimized experimental conditions were applied to the preparation of biological relevant aminoalkyl-HMPPs. A preliminary study of the complexation to hydroxyapatite (bone matrix) was carried out in order to verify its lower affinity towards bone compared to bisphosphonate molecules. Moreover, in vitro anti-tumor activity study revealed encouraging antiproliferative activities on three human cancer cell lines (breast, pancreas and lung).

Optimized synthesis of etidronate

The synthesis of Etidronate (as the disodium salt) by the reaction of acetic acid with phosphorus trichloride/phosphorus acid in methanesulfonic acid was studied and optimized. We showed that it is enough to use 3.2 equivalents of the phosphorus trichlori

Aminohydroxypropane esters of hydroxyethylidenebisphosphoric acid.

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