37940-49-1Relevant academic research and scientific papers
Alpha-substituted beta-aminoethyl phosphonate derivatives
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, (2008/06/13)
The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins
Alpha-substituted beta-aminoethyl phosphonate derivatives
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, (2008/06/13)
The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins
Process for the preparation of hydroxybenzylphosphonates
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, (2008/06/13)
A process for the preparation of compounds of the general formula I STR1 in which R1 is hydrogen or methyl, R2 and R3 independently of one another are C1 -C18 alkyl, C5 -C8 cycloalkyl, phenyl, C7 -C9 phenylalkyl or halogen, R2 is additionally hydrogen and R7 and R8 independently of one another are C1 -C18 alkyl, phenyl or C7 -C18 alkylphenyl, which comprises reacting a phenol of the formula II STR2 in which R1 to R3 have the meaning described above, with formaldehyde or paraformaldehyde, an amine of the formula III in which R4 is C1 -C4 alkyl and R5 and R6 independently of one another are hydrogen or C1 -C4 alkyl, and a phosphite of the formula IV STR3 in which R7 and R8 have the meaning described above and R9 has the meaning given for R7 and R8, at a temperature of 0°-200° C. Some compounds of the formula I are novel.
Process for the preparation of sterically hindered hydroxybenzylphosphonates
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, (2008/06/13)
A process for the preparation of hydroxybenzylphosphonates of forula STR1 by reacting Mannich base of formula STR2 with as trialkyl phosphite of formula STR3 wherein R1 and R2 are each independently of the other C1 -C12 alkyl or, when taken together form a piperidinyl or morpholinyl radical, and R5, R6 and R7 are each independently of one another C1 -C4 alkyl, which reaction is carried out in the presence of a carboxylic anhydride (IV). The compounds of formula I may suitably be used as processing stabilizers for plastics.
