37941-52-9Relevant academic research and scientific papers
Co-ordination Properties of Cyclopeptides. Formation and Stability of Zinc(II) and Copper(II) Complexes of Histidine-containing Cyclopeptides, or Imidazole
Arena, Giuseppe,Impellizzeri, Giuseppe,Maccarrone, Giuseppe,Pappalardo, Giuseppe,Rizzarelli, Enrico
, p. 1227 - 1230 (1994)
In order to obtain an improved understanding of the complexing properties of cyclopeptides involved in biological processes, the interaction of zinc(II) with cyclo(L-histidyl-L-histidyl) was studied by potentiometric and calorimetric techniques in aqueous solution.Comparison between the thermodynamic parameters of the complexes formed with those for analogous species formed with cyclo(glycyl-L-histidyl) allowed evidence to be obtained for the formation of chelate rings of unusual size.The thermodynamic quantities associated with copper(II) complex formation with cyclo(-Gly-His-) were determined.The role of the different stereochemical requirements of copper(II) and zinc(II) in the formation of large chelate rings was assessed by means of previously reported data concerning the copper(II)-cyclo(-His-His-) complexes.
l-Histidyl-glycyl-glycyl-l-histidine. Amino-acid structuring of the bleomycin-type pentadentate metal-binding environment capable of efficient double-strand cleavage of plasmid DNA
Ida, Satomi,Iwamaru, Kana,Fujita, Mikako,Okamoto, Yoshinari,Kudo, Yuri,Kurosaki, Hiromasa,Otsuka, Masami
, p. 8 - 14 (2015)
Abstract A tetrapeptide, l-histidyl-glycyl-glycyl-l-histidine (HGGH), was synthesized and the pUC19 plasmid DNA cleaving activity by copper(II) complex of HGGH (Cu(II)-HGGH) was investigated. Cu(II)-HGGH showed bleomycin-like DNA cleaving activity and, at
Protease-catalysed synthesis of peptides containing histidine and lysine
Beck-Piotraschke, Karin,Jakubke, Hans-Dieter
, p. 1505 - 1518 (2007/10/03)
The kinetically controlled α-chymotrypsin- and trypsin-catalysed syntheses of peptides starting from simple acyl donor esters containing histidine at the P1-position (nomenclature according to Schechter and Berger) and lysine derivatives as amino components were examined on the basis of their kinetic parameters. Despite higher specificity constants (k(cat)/K(M)) of trypsin-catalysed ester hydrolysis, α-chymotrypsin- catalysed acyl transfer to N(ε)unprotected lysine derivatives gave higher peptide yields as compared to trypsin-catalysed reactions, whereas in acyl transfer to N(ε)-protected lysine derivatives the trypsin-catalysed reaction gave higher yields. α-Chymotrypsin-catalysed acyl transfer reactions in frozen systems demonstrated the yield-enhancing effect of freezing. Using specific ester leaving groups, both the amount of enzyme and the reaction time can be reduced. In frozen systems the ε-amino function of H-Lys-OH acts as an acyl acceptor at pH ≤9.
Thermodynamic and (1)H NMR Study of Proton Complex Formation of Histidine-containing Cyclodipeptides in Aqueous Solution
Arena, Giuseppe,Impellizzeri, Giuseppe,Maccarrone, Giuseppe,Pappalardo, Giuseppe,Sciotto, Domenico,Rizzarelli, Enrico
, p. 371 - 376 (2007/10/02)
A thermodynamic and (1)H NMR study of proton complex formation in aqueous solution of some L-histidine-containing cyclic L-dipeptides has been carried out.The enthalpic and entropic changes associated with protonation of the cyclodipeptides, obtained by potentiometric and calorimetric measurements, together with the (1)H NMR data and NOESY experiments, enable the role played by non-covalent interactions in proton complex formation to be assessed.In addition, a comparison with c(Gly-His) permits the influence of side-chain residues on the conformation of protonated species to be observed.
