37952-36-6Relevant articles and documents
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1
van der Vlag, Ramon,Guo, Hao,Hapko, Uladzislau,Eleftheriadis, Nikolaos,Monjas, Leticia,Dekker, Frank J.,Hirsch, Anna K.H.
, p. 45 - 55 (2019/04/27)
Human 15-lipoxygenase-1 (15-LOX-1) is a mammalian lipoxygenase which plays an important regulatory role in several CNS and inflammatory lung diseases. To further explore the role of this enzyme in drug discovery, novel potent inhibitors with favorable phy