379693-23-9Relevant academic research and scientific papers
Asymmetric Diels-Alder reactions of optically active oxazolidinone-derived vinylsulfonamides
Bernabeu, M. Carmen,Chinchilla, Rafael,Falvello, Larry R.,Najera, Carmen
, p. 1811 - 1815 (2007/10/03)
Chiral vinylsulfonamides bearing an oxazolidin-2-one moiety derived from (R)-2-phenylglycinol and (1R,2S)-norephedrine have been employed as dienophiles in asymmetric Diels-Alder reactions at normal pressure affording d.e.s of up to 99% when EtAlCl2 or Et2AlCl ewre employed as Lewis acids. Theoretical calculations justify the observed enantio- and diastereoselectivity.
