3800-15-5

Usage

Uses

Used in Research and Drug Development:
1-(4-FLUOROPHENYL)-4-MORPHOLINO-1-BUTANONE is used as a potential inhibitor or modulator of biological processes in research and drug development. Its specific biological activity and potential uses are still under investigation, but it has shown promise as a therapeutic agent for the treatment of various diseases and conditions.
Used in Medicinal Chemistry and Pharmaceutical Development:
In the field of medicinal chemistry and pharmaceutical development, 1-(4-FLUOROPHENYL)-4-MORPHOLINO-1-BUTANONE may have applications due to its unique chemical structure and potential to interact with biological targets. Its properties are being explored for the development of new drugs and therapeutic agents.

InChI:InChI=1/C14H18FNO2/c15-13-5-3-12(4-6-13)14(17)2-1-7-16-8-10-18-11-9-16/h3-6H,1-2,7-11H2

Upstream product

• 1219-37-0 1-(4-fluorophenyl)-4-(morpholin-4-yl)butan-1-one hydrochloride 

Relevant academic research and scientific papers

HETEROAROMATIC COMPOUNDS, METHOD FOR PREPARING THE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND METHOD FOR TREATING ACUTE AND CHRONIC PAIN

The present invention refers to a compound of formula (I) or a pharmaceutically acceptable salt thereof, having analgecic activity. Particularly, the compounds of the instant invention are useful to treat or prevent acute and chronic pain, especially neuropathic pain. Additionally, the present invention provides a procces for preparing the compounds, a pharmaceutical composition that comprises a compound of formula (I), and a method for treatment of acute and chronic pain.

[4-aminobutyrophenones with hypotensive activity]

A series of new butyrophenones was synthesized, the aim being to reduce neuroleptic activity and enhance the hypotensive effects of this class of drugs. The compounds were screened for toxicity according to the Irwin scheme and tested in anaesthetized cats for their effects on systemic arterial pressure. The most interesting compound, i.e. 1-(4'-fluorobenzoyl)-3-pyrrolidinyl-propane, was tested also in anaesthetized rabbits, cats, and dogs and in concious dogs. Moreover its central nervous system effects were tested in rats and mice. The compound proved practically devoid of neurological effects and showed interesting hypotensive activity.