380220-75-7Relevant academic research and scientific papers
A short and convenient synthesis of new 1,2-disubstituted carbocyclic nucleoside analogues of pyrimidine based on a cyclopentene ring
Gonzalez-Moa,Besada,Teijeira,Teran,Uriarte
, p. 543 - 548 (2004)
The synthesis of a new series of 1,2-disubstituted carbonucleoside analogues, pyrimidines of general structure I, is reported. These compounds were prepared in good yield from (±)-6-azabicyclo[3.2.0]hept-3-en-7-one (1) via two synthetic routes that involve NaBH4-mediated C-N bond cleavage as the key step. The uracil derivative Ia was halogenated with Cl, Br, and I at position 5 by treatment with the corresponding N-halosuccinimide.
