38024-35-0

Upstream product

• 62-53-3 aniline 
• 20923-20-0 α-carboxamido-α-phenylhydrazonoacetonitrile 

Downstream Products

• 143232-59-1 4-amino-3-cinnolinecarboxylic acid 
• 874903-53-4 2-phenyl-pyrimido[5,4-c]cinnolin-4(3H)-one 
• 874903-56-7 2-(4-chlorophenyl)-pyrimido[5,4-c]cinnolin-4-ol 
• 874903-54-5 2-(4-methoxyphenyl)-pyrimido[5,4-c]cinnolin-4-ol 
• 874903-55-6 2-(2-methoxyphenyl)-pyrimido[5,4-c]cinnolin-4-ol 
• 874903-61-4 4-chloro-2-(2-methoxyphenyl)-pyrimido[5,4-c]cinnoline 
• 874903-60-3 4-chloro-2-(4-methoxyphenyl)-pyrimido[5,4-c]cinnoline 
• 874903-62-5 4-chloro-2-(4-chlorophenyl)-pyrimido[5,4-c]cinnoline 
• 874903-59-0 4-chloro-2-phenyl-pyrimido[5,4-c]cinnoline 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS

The present invention relates to compounds of the general formula (1) wherein the variables are defined as given in the description and claims. The invention further relates to uses of and to, processes and intermediates related to compounds of the general formula (I), wherein Q is wherein the substituents of I, Ia and Ib are as defined in description and claims.

Synthesis of some 1,2,4-triazolopyrimidocinnolines

Substituted 1,2,4-triazolopyrimidocinnolines (6a-d) have been synthesized from the corresponding arylhydrazino(cyano)acetamides (1a-d).The hydrazino derivatives (5a-d) prepared fron 1a-d on refluxing in triethylorthoformate undergo smooth cyclization to yield the expected 1,2,4-triazolopyrimidocinnolines (6a-d).The structures of all compounds have been established on the basis of their elemental analysis and spectral data.'

Synthesis, structures and biological activity of some 4-amino-3-cinnolinecarboxylic acid derivatives, part 1

This work describes the synthesis of 4-amino-3-cinnolinecarboxamides, which were then hydrolyzed to corresponding 4-amino-3-cinnolinecarboxylic acids. Several compounds were tested for their antibacterial and antifungal activity, and for the central nervous system effect.

Synthesis and Biological Properties of 2-Mercaptopyrimidocinnolin-4(3H)-ones and their S-Alkyl Derivatives

The synthesis of some hitherto unreported 2-mercaptopyrimidocinnolin-4(3H)-ones (4) is described.Treatment with alkyl halides under basic conditions yielded the S-alkyl derivatives.The synthesised compounds are characterised by spectral and analytical data.Most of the compounds of the series exhibit promising antibacterial and antifungal activities.

Synthesis of 4-Aminocinnolines from (Arylhydrazono)(cyano)acetic Acid Derivatives

The intramolecular Friedel-Crafts reaction of (arylhydrazono)(cyano)acetamides and -malononitriles 1 yields the 4-amino-3-cinnolinecarboxylic acid derivatives 2.Toluene as solvent takes part in the reaction of 1d and e and forms the 4-amino-3-cinnolyl p-t