380380-64-3

Basic information

• Product Name: 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE
• Synonyms: Pyridine, 5-broMo-2-(2-Methyl-2H-tetrazol-5-yl)-;2-(2-Methyl-5-tetrazolyl)-5-bromopyridine;5-broMo-2-(2-Methyl-2H-tetrazol-5-yl)pyridine (c);Tedizolid interMediate;Torezolid Intermediate2;Methyl-5- (5-bromo-2-yl) tetrazole
• CAS NO: 380380-64-3
• Molecular Formula: C₇H₆BrN₅
• Molecular Weight: 240.07
• Product Categories: Tedizolid intermediates
• Mol File: 380380-64-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 375.19 °C at 760 mmHg
• Flash Point: 180.709 °C
• Appearance: /
• Density: 1.85±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.759
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.94±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE(380380-64-3)
• EPA Substance Registry System: 5-BROMO-2-(2-METHYL-2H-TETRAZOL-5-YL)-PYRIDINE(380380-64-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 380380-64-3(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)-pyridine is a chemical compound with the molecular formula C7H6BrN5. It is a pyridine derivative that contains a bromine atom, a methyl group, and a tetrazole ring. 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)-pyridine has a wide range of applications in the pharmaceutical industry, where it is used as a building block for the synthesis of various drug compounds. It is also used in academic and industrial research as a reagent and intermediate in organic synthesis. Additionally, 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)-pyridine has potential application as an agrochemical and in the development of new materials.

InChI:InChI=1/C7H6BrN5/c1-13-11-7(10-12-13)6-3-2-5(8)4-9-6/h2-4H,1H3

Upstream product

• 1374651-37-2 5-bromo-2-(2H-tetrazol-5-yl)pyridine ammonium salt 
• 380380-60-9 5-bromo-2-(2H-tetrazol-5-yl)pyridine 
• 50-00-0 formaldehyd 
• 74-88-4 methyl iodide 
• 97483-77-7 2-Cyano-5-bromopyridine 
• 77-78-1 dimethyl sulfate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1354927-82-4 ethyl 5-bromopicolinimidate 
• 624-28-2 2,5-dibromopyridine 
• 380380-60-9 2-(1,2,3,4-tetrazol-5-yl)-5-bromopyridine 

Downstream Products

• 1220910-89-3 3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester 
• 717116-80-8 (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(isoxazol-3-yl)oxymethyloxazolidin-2-one 
• 856867-59-9 (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one 
• 1293990-05-2 (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(azidomethyl)oxazolidin-2-one 
• 1293990-06-3 (S)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(aminomethyl)oxazolidin-2-one 
• 1293990-07-4 (S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-methoxyacetamide 
• 1293990-08-5 (S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)furan-2-carboxamide 
• 1293990-09-6 (S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)thiopene-2-carboxamide 
• 1293990-10-9 (S)-2-(benzyloxy)-N-((3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide 
• 1293990-11-0 (S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-hydroxyacetamide 

Relevant articles and documents

Tedizolid phosphate impurity as well as preparation method and application thereof

The invention provides a tedizolid phosphate impurity as well as a preparation method and application thereof, and belongs to the field of chemical pharmacy. The structural formula of the impurity isshown as a formula I in the specification. The impurity is generated in the process of synthesizing a 2-(2-methyl-2H-tetrazole-5-yl)-5-(4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborocyclopentane-2-yl) pyridine intermediate, and the quality of a product is seriously influenced by the impurity. The impurity is synthesized and separated, the purity is higher than 96%, and the quality requirements of impurity reference substances related to national pharmacopoeia and Chinese pharmacopoeia are met. The impurity preparation process is simple and stable and good in repeatability; and the prepared impurity2-(2-methyl-tetrazole)-5-azido pyridine can be used as a reference substance to be applied to quality control of tedizolid phosphate API, crude drugs and preparations, can also provide a reliable monitoring means for process research and promote the process optimization and determination procedures and has a good application prospect.

TRIAZOLOTRIAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS

The present invention provides triazolotriazine derivatives of formula (1) as A2A receptor antagonists. Compounds of formula (1) and pharmaceutical compositions including the compounds can be used for the treatment of disorders related to A2A receptor hyp

Synthesis method of tedizolid intermediate

The invention provides a synthesis method of a tedizolid intermediate. The synthesis method comprises the following steps: Step A: generating a compound (II) or acidic salt of the compound (II) through addition reaction of a cyano group in a compound (I) and alcohol; Step B: generating a compound (III) by replacing an alkoxy on the compound (II) or the acidic salt of the compound (II) with a hydrazine group or a methylhydrazine group; Step C: generating a tedizolid intermediate (IV) through reaction of the compound (III) and sodium nitrite under an acidic condition. The overall reaction formula is shown in the original specification. According to the synthesis method disclosed by the invention, the problems of easy explosion and poison of reaction reagent, difficulty in separation of a methyl-isomer by-product and so on are solved.