38040-53-8Relevant academic research and scientific papers
Construction of N-C Axial Chirality through Atroposelective C-H Olefination of N-Arylindoles by Palladium/Amino Acid Cooperative Catalysis
Zhang, Jitan,Xu, Qiaoqiao,Wu, Jiaping,Fan, Jian,Xie, Meihua
supporting information, p. 6361 - 6365 (2019/08/20)
Direct construction of N-C axial chirality via Pd-catalyzed atroposelective C-H olefination of N-arylindoles is reported. The crucial role of chiral amino acid as a cocatalyst in the regio- and stereocontrol has been disclosed. In this reaction, a wide range of arylindoles and functional alkenes could be well tolerated. Moreover, the practicality and synthetic value of this process were demonstrated by the divers and simple transformations of the products.
Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT 7 receptor ligands
Paillet-Loilier, Magalie,Fabis, Frederic,Lepailleur, Alban,Bureau, Ronan,Butt-Gueulle, Sabrina,Dauphin, Francois,Delarue, Catherine,Vaudry, Hubert,Rault, Sylvain
, p. 3753 - 3757 (2007/10/03)
Virtual screening studies have identified a series of phenylpyrroles as novel 5-HT7 receptor ligands. The synthesis and the affinity for the 5-HT7 receptor of these phenylpyrroles are described. Some of these compounds exhibited high affinity for the 5-HT7 receptors.
