380415-20-3Relevant academic research and scientific papers
A novel use of Grubbs' carbene. Application to the catalytic deprotection of tertiary allylamines
Alcaide, Benito,Almendros, Pedro,Alonso, Jose M.,Aly, Moustafa F.
, p. 3781 - 3784 (2001)
Figure presented The first examples accounting for the catalytic deprotection of allylic amines by using reagents different from palladium catalysts have been achieved via Grubbs' carbene-mediated reaction. The current mechanistic hypothesis invokes a nitrogen-assisted ruthenium-catalyzed isomerization, followed by hydrolysis of the enamine intermediate. We believe that an unprecedented mode of ring opening of the ruthena-cyclobutane was involved.
