380600-71-5Relevant academic research and scientific papers
Water-soluble chiral ruthenium(II) phenyloxazoline complex: Reusable and highly enantioselective catalyst for intramolecular cyclopropanation reactions
Abu-Elfotoh, Abdel-Moneim,Nguyen, Diem Phuong Thi,Chanthamath, Soda,Phomkeona, Kesiny,Shibatomi, Kazutaka,Iwasa, Seiji
supporting information, p. 3435 - 3439 (2013/03/13)
The intramolecular cyclopropanation of various trans-allylic diazoacetates and alkenyl diazoketones has been achieved with excellent enantioselectivities of up to 98% ee and in quantitative yields by using a water-soluble ruthenium(II)/hydroxymethyl(phenyl)oxazoline catalyst in a water/ether biphasic medium. The catalyst could be reused at least five times.
Asymmetric intramolecular cyclopropanation of diazo compounds with metallosalen complexes as catalyst: Structural tuning of salen ligand
Saha, Biswajit,Uchida, Tatsuya,Katsuki, Tsutomu
, p. 823 - 836 (2007/10/03)
Intramolecular cyclopropanation of alkenyl α-diazoacetates and alkenyl diazomethyl ketones was examined by using optically active (ON+)Ru(II)(salen) and Co(II)(salen) complexes as catalysts. For the cyclization of 2-alkenyl α-diazoacetates, Co(II)(salen) complexes 9 and 10 were found to be superior catalysts to the corresponding (ON+)Ru(II)(salen) complexes 4 and 5. On the other hand, (ON+)Ru(II)(salen) complex 2 was found to be the catalyst of choice for the cyclization of 3-alkenyl diazomethyl ketones, and complex 4 was found to be a good catalyst for the cyclization of (E)-4-alkenyl diazomethyl ketones. The present study demonstrates that metallosalen complexes, especially optically active (ON+)Ru(II)(salen) and Co(II)(salen) complexes, can serve as efficient catalysts for the cyclization of alkenyl diazocarbonyl compounds, if a suitable salen ligand is used as the chiral auxiliary.
