380605-28-7

Basic information

• Product Name: 4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE
• Synonyms: 4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE;N-Cyclopropyl-3-nitropyridin-4-amine
• CAS NO: 380605-28-7
• Molecular Formula: C₈H₉N₃O₂
• Molecular Weight: 179.18
• EINECS: 200-158-5
• Mol File: 380605-28-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 345.645°C at 760 mmHg
• Flash Point: 162.841°C
• Appearance: /
• Density: 1.453
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.701
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE(380605-28-7)
• EPA Substance Registry System: 4-(CYCLOPROPYLAMINO)-3-NITROPYRIDINE(380605-28-7)

Safety Data

• Hazardous Substances Data: 380605-28-7(Hazardous Substances Data)

Usage

General Description

4-(Cyclopropylamino)-3-nitropyridine is a specialized organic compound that features a pyridine nucleus attached with a nitro group at the 3rd position and a cyclopropylamino group at the 4th position. Pyridine is a basic heterocyclic organic compound similar to benzene and nitrogen, it owns aromatic quality like that of benzene, and especially versatile due to the presence of a nitrogen atom. Nitro groups ordinarily play a part in increasing chemical reactivity. The cyclopropylamino component can affect the compound's biological activity. Due to its unique structure, this chemical might be used in various chemical reactions and in the development of other compounds, often in the field of pharmaceutical or chemical research. However, specific applications and potential properties of this chemical might depend upon the context and exact area of use.

InChI:InChI=1/C8H9N3O2/c12-11(13)8-5-9-4-3-7(8)10-6-1-2-6/h3-6H,1-2H2,(H,9,10)

Upstream product

• 5435-54-1 4-hydroxy-3-nitropyridine 
• 31872-62-5 4-methoxy-3-nitro-pyridine 
• 765-30-0 Cyclopropylamine 

Downstream Products

• 797032-05-4 C₁₁H₁₃N₃O₄ 
• 1383451-33-9 4-(5-bromo-2-((1-cyclopropyl-2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)methyl)-1H-indol-1-yl)butyl 4-methylbenzensulfonate 
• 146950-68-7 N⁴-cyclopropylpyridin-3,4-diamine 

Relevant articles and documents

1-PYRAZOLYL, 5-, 6- DISUBSTITUTED INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6- disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

QUINAZOLINE BASED RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I), wherein R1, R2, R3, R4 and n are defined herein, are useful as inhibitors of RSV.

Non-benzimidazole containing inhibitors of respiratory syncytial virus

Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a good potency and pharmacokinetic profile in the rat.