380605-29-8

Basic information

• Product Name: 1-Cyclopropyl-1,3-dihydroimidazo[4,5-c]pyridine-2-one
• Synonyms: 1-Cyclopropyl-1,3-dihydroimidazo[4,5-c]pyridine-2-one;1-CYCLOPROPYL-1,3-DIHYDROIMIDAZO[4,5-C]PYRIDIN-2-ONE;1-Cyclopropyl-1,3-dihydro-2H-iMidazo[4,5-c]pyridin-2-one
• CAS NO: 380605-29-8
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.18726
• Mol File: 380605-29-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.433g/cm³
• Refractive Index: 1.681
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Cyclopropyl-1,3-dihydroimidazo[4,5-c]pyridine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropyl-1,3-dihydroimidazo[4,5-c]pyridine-2-one(380605-29-8)
• EPA Substance Registry System: 1-Cyclopropyl-1,3-dihydroimidazo[4,5-c]pyridine-2-one(380605-29-8)

Safety Data

• Hazardous Substances Data: 380605-29-8(Hazardous Substances Data)

Usage

Uses

1-Cyclopropyl-1,3-dihydroimidazo[4,5-c]pyridine-2-one is a novel inhibitor of human La protein with anti-viral activity.

InChI:InChI=1/C9H9N3O/c13-9-11-7-5-10-4-3-8(7)12(9)6-1-2-6/h3-6H,1-2H2,(H,11,13)

Upstream product

• 5435-54-1 4-hydroxy-3-nitropyridine 
• 31872-62-5 4-methoxy-3-nitro-pyridine 

Downstream Products

• 1383451-33-9 4-(5-bromo-2-((1-cyclopropyl-2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)methyl)-1H-indol-1-yl)butyl 4-methylbenzensulfonate 

Relevant articles and documents

1-PYRAZOLYL, 5-, 6- DISUBSTITUTED INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6- disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

QUINAZOLINE BASED RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I), wherein R1, R2, R3, R4 and n are defined herein, are useful as inhibitors of RSV.

INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

Indoles having inhibitory activity on RSV replication and having the formula I the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.