380605-59-4

Basic information

• Product Name: (4-BroMo-1,1-diMethylbutoxy)(1,1-diMethylethyl)diMethylsilane
• Synonyms: (4-BroMo-1,1-diMethylbutoxy)(1,1-diMethylethyl)diMethylsilane;(4-Bromo-1,1-dimethyl-butoxy)-tert-butyl-dimethyl-silane
• CAS NO: 380605-59-4
• Molecular Formula: C12H27BrOSi
• Molecular Weight: 295.33168
• Product Categories: Aliphatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 380605-59-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: (4-BroMo-1,1-diMethylbutoxy)(1,1-diMethylethyl)diMethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BroMo-1,1-diMethylbutoxy)(1,1-diMethylethyl)diMethylsilane(380605-59-4)
• EPA Substance Registry System: (4-BroMo-1,1-diMethylbutoxy)(1,1-diMethylethyl)diMethylsilane(380605-59-4)

Safety Data

• Hazardous Substances Data: 380605-59-4(Hazardous Substances Data)

Usage

Uses

(4-Bromo-1,1-dimethylbutoxy)(1,1-dimethylethyl)dimethylsilane is used in the preparation of oxysterol agonists of hedgehog signaling.

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 21871-76-1 5-bromo-2-methylpentane-2-ol 

Relevant articles and documents

Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway

Oxysterols (OHCs) are byproducts of cholesterol oxidation that are known to activate the Hedeghog (Hh) signaling pathway. While OHCs that incorporate hydroxyl groups throughout the scaffold are known, those that act as agonists of Hh signaling primarily contain a single hydroxyl on the alkyl side chain. We sought to further explore how side chain hydroxylation patterns affect oxysterol-mediated Hh activation, by performing a structure-activity relationship study on a series of synthetic OHCs. The most active analogue, 23(R)-OHC (35), demonstrated potent activation of Hh signaling in two Hh-dependent cell lines (EC50 values 0.54-0.65 μM). In addition, OHC 35 was approximately 3-fold selective for the Hh pathway as compared to the liver X receptor, a nuclear receptor that is also activated by endogenous OHCs. Finally, 35 induced osteogenic differentiation and osteoblast formation in cultured cells, indicating functional agonism of the Hh pathway.

2-Methylene-20(21)-Dehydro-19-Nor-Vitamin D Analogs

This invention discloses 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-20(21)-dehydro-19-nor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits relatively high transcription a