38061-36-8

Basic information

• Product Name: 2-(2-NAPHTHYL)-2-OXO-1-ETHANAMINIUM CHLORIDE
• Synonyms: 2-AMINO-1-(2-NAPHTHYL)-1-ETHANONE HYDROCHLORIDE;2-(2-NAPHTHYL)-2-OXO-1-ETHANAMINIUM CHLORIDE;2-AMINO-2'-ACETONAPHTHONE HYDROCHLORIDE;2-Amino-1-naphthalen-2-yl-ethanone
• CAS NO: 38061-36-8
• Molecular Formula: C₁₂H₁₁NO*ClH
• Molecular Weight: 221.68
• Mol File: 38061-36-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 226-228°C
• Boiling Point: 361.3°C at 760 mmHg
• Flash Point: 172.3°C
• Appearance: /
• Density: 1.166g/cm³
• Vapor Pressure: 2.09E-05mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 2-(2-NAPHTHYL)-2-OXO-1-ETHANAMINIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-NAPHTHYL)-2-OXO-1-ETHANAMINIUM CHLORIDE(38061-36-8)
• EPA Substance Registry System: 2-(2-NAPHTHYL)-2-OXO-1-ETHANAMINIUM CHLORIDE(38061-36-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 38061-36-8(Hazardous Substances Data)

Usage

General Description

2-(2-Naphthyl)-2-Oxo-1-Ethanaminium Chloride is a complex chemical compound. Its molecular formula is C12H12OClNO with a molecular weight of approximately 235.68. As the name suggests, this compound is derived from ethanaminium and naphthalene rings, bearing a chloride as the counterion which gives it its salt-like properties. 2-(2-NAPHTHYL)-2-OXO-1-ETHANAMINIUM CHLORIDE may exhibit reactive properties typical of ketones and quaternary ammonium salts. It is typically used in laboratory settings for research, largely due to these unique characteristics. Precautions should be taken to ensure proper handling and storage as it can pose potential risks if mishandled. While specific interactions and properties may vary greatly depending on the circumstance, the fundamental structure of 2-(2-Naphthyl)-2-Oxo-1-Ethanaminium Chloride allows it to be a versatile tool within chemical research.

InChI:InChI=1/C12H11NO/c13-8-12(14)11-6-5-9-3-1-2-4-10(9)7-11/h1-7H,8,13H2

Upstream product

• 55117-00-5 2-azido-1-(2-naphthyl)ethanone 
• 613-54-7 2-Bromo-2'-acetonaphthone 
• 85199-46-8 1-(naphthalen-2-yl)-2-nitroethan-1-one 

Downstream Products

• 1430730-99-6 4(5)-(2-naphthyl)-2-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)imidazole 
• 874812-95-0 3,5-Dimethyl-N-(2-naphthalen-2-yl-2-oxo-ethyl)-benzenesulfonamide 
• 67607-60-7 2-(4-difluoromethanesulfonyl-phenyl)-5-naphthalen-2-yl-oxazole 
• 97101-99-0 2-amino-1-(2-naphthyl)ethanol 
• 4899-26-7 (S)-(+)-2-amino-1-(2'-naphthyl)ethanol 
• 5696-74-2 (1RS)-2-amino-1-(2-naphthyl)ethanol 

Relevant articles and documents

Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase

C-β-D-Glucopyranosyl pyrrole derivatives were prepared in the reactions of pyrrole, 2-, and 3-aryl-pyrroles with O-peracetylated β-D-glucopyranosyl trichloroacetimidate, while 2-(β-D-glucopyranosyl) indole was obtained by a cross coupling of O-perbenzylated β-D-glucopyranosyl acetylene with N-tosyl-2-iodoaniline followed by spontaneous ring closure. An improved synthesis of O-perbenzoylated 2-(β-D-glucopyranosyl) imidazoles was achieved by reacting C-glucopyranosyl formimidates with α-aminoketones. The deprotected compounds were assayed with isoforms of glycogen phosphorylase (GP) to show no activity of the pyrroles against rabbit muscle GPb. The imidazoles proved to be the best known glucose derived inhibitors of not only the muscle enzymes (both a and b) but also of the pharmacologically relevant human liver GPa (Ki?=?156 and 26?nM for the 4(5)-phenyl and -(2-naphthyl) derivatives, respectively). An X-ray crystallographic study of the rmGPb-imidazole complexes revealed structural features of the strong binding, and also allowed to explain the absence of inhibition for the pyrrole derivatives.

Asymmetric hydrogenation of α-primary and secondary amino ketones: Efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine

Two ss-receptor agonists (-)-denopamine and (-)-arbutamine were prepared in good yields and enantioselectivities by asymmetric hydrogenation of unprotected amino ketones for the first time by using Rh catalysts bearing electron-donating phosphine ligands. A series of α-primary and secondary amino ketones were synthesized and hydrogenated to produce various 1,2-amino alcohols in good yields and with good enantioselectivies. This Rh electron-donating phosphine-catalyzed asymmetric hyderogenation repI resents one of the most promising and convenient approaches towards the asymmetric synthesis of chiral amino alcohols.

The significance of the imidazole ring in anticonvulsant activity of (arylalkyl)imidazoles

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