380610-92-4

Basic information

• Product Name: Carbamic acid, [(1R)-1-(3-bromophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(1R)-1-(3-bromophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester (9CI);Carbamic acid, [(1R)-1-(3-bromophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester;(R)-tert-Butyl (1-(3-bromophenyl)-2-hydroxyethyl)carbamate
• CAS NO: 380610-92-4
• Molecular Formula: C13H18BrNO3
• Molecular Weight: 316.19092
• Mol File: 380610-92-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Carbamic acid, [(1R)-1-(3-bromophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R)-1-(3-bromophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester (9CI)(380610-92-4)
• EPA Substance Registry System: Carbamic acid, [(1R)-1-(3-bromophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester (9CI)(380610-92-4)

Safety Data

• Hazardous Substances Data: 380610-92-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1098108-56-5 (S)-2-bromo-1-(3-bromophenyl)ethanol 
• 18523-22-3 2,3'-dibromoacetophenone 
• 131567-05-0 (S)-(+)-2-(3-bromophenyl)oxirane 
• 209963-04-2 (R)-2-amino-2-(3-bromophenyl)ethanol 
• 2095772-98-6 (S)-2-amino-2-(3-bromophenyl)ethanol hydrochloride 
• 209963-04-2 (S)-2-amino-2-(3-bromophenyl)ethan-1-ol 

Relevant articles and documents

CTPS1 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CPTS1, and the treatment of CPTS1-mediated disorders.

Synthesis of enantiopure 1,2-azido and 1,2-amino alcohols via regio- and stereoselective ring-opening of enantiopure epoxides by sodium azide in hot water

A practical and convenient method for the efficient and regio- and stereoselective ring-opening of enantiopure monosubstituted epoxides by sodium azide under hydrolytic conditions is reported. The ring-opening of enantiopure styryl and pyridyl (S)-epoxides by N3- in hot water takes place preferentially at the internal position with complete inversion of configuration to produce (R)-2-azido ethanols with up to 99% enantio- and regioselectivity, while the (S)-adamantyl oxirane provides mainly the (S)-1-adamantyl-2-azido ethanol in excellent yield. In general, 1,2-amino ethanols were obtained in high yield and excellent enantiopurity by the reduction of the chiral 1,2-azido ethanols with PPh3 in water/THF, and then converted into the Boc or acetamide derivatives.