380663-67-2

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 171082-32-9 2-dicyanomethylidene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran 
• 115-22-0 3-Hydroxy-3-methyl-2-butanone 

Relevant academic research and scientific papers

D-π-A solvatochromic charge transfer dyes containing a 2-cyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran acceptor

The preparation and solvatochromic behavior of novel, intramolecular charge transfer dyes obtained by the condensation of 2-cyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran with 4-dimethylamino benzaldehyde and 9-formyljulolidine are described. The absorption and fluorescence emission spectra of the dyes were studied in solvents of differing polarity. The dyes exhibited positive solvatochromism and their solvatochromic properties are discussed with the aid of semiempirical calculations. The HOMO and LUMO values of the dyes were obtained using both cyclic voltammetry and theoretical calculations; the electrochemical results were in agreement with both observed values and theoretical calculations. pH molecular switching was achieved by modulation of intramolecular charge transfer by means of protonation/deprotonation in DMSO solution.

Synthesis, optical and electrochemical properties of a series of push-pull dyes based on the 2-(3-cyano-4,5,5-trimethylfuran-2(5H)-ylidene)malononitrile (TCF) acceptor

A series of chromophores was designed and synthesized using 2-(3-cyano-4,5,5-trimethylfuran-2 (5H) -ylidene) malononitrile (TCF) as the electron acceptor and differing from each other by the use of thirteen different electron donors. The different dyes were characterized for their optical and electrochemical properties and theoretical calculations were also carried out to support the experimental results. By changing the electron donor in the thirteen dyes, chromophores absorbing between 430 nm and 700 nm could be synthesized. Solvatochromism of the different dyes was analyzed in 23 solvents of different polarity and a positive solvatochromism was determined for all chromophores using the semi-empirical solvent polarity scales based on the Kamlet-Taft parameters (π *) or the Catalan parameters (SdP and SPP).

A highly selective colorimetric and far-red fluorescent probe for imaging bisulfite in living cells

The development of probes for specific bisulfite (HSO3 -) detection is of great importance, due to its toxicity in the environment and important biological functions in living systems. In the present study, we developed a highly selective colorimetric and far-red fluorescent probe (1) for the determination of HSO3- in aqueous solution and living cells. The excellent properties of our proposed probe can be listed as follows. Firstly, probe 1 showed excellent selectivity for HSO 3- over various other species including Cys, GSH, S 2-, SO32-, and ROS, which might be ascribed to the introduction of a receptor of the electron-poor CC double bond for HSO 3-. Secondly, our proposed probe possesses the higher molar absorption coefficient, and it can serve as a sensitive naked-eye probe for HSO3-. So, probe 1 would provide a convenient and promising method for the visual detection of HSO 3- and the toxic gaseous SO2 in the environment. Thirdly, probe 1 has a long-wavelength emission spectrum at 643 nm, and thus it possesses many superiorities over short-wavelength ones in bioimaging. Finally, probe 1 exhibited excellent cell permeability and low cytotoxicity for the successful detection of HSO3- in living RAW 264.7 macrophage cells, implying that this probe would be of great benefit to biological researchers for investigating the detailed biological and pharmacological functions of HSO3- in biological systems. the Partner Organisations 2014.

A ratiometric and colorimetric fluorescent probe designed based on FRET for detecting SO32?/HSO3? in living cells and mice

Based on the principle of FRET, we have developed a ratiometric and colorimetric fluorescent probe TFBN, which can specifically recognize SO2 derivatives (SO32?/HSO3?), and exhibit a transition from red to green fluorescence under 405 nm excitation. The probe TFBN owns the advantages of short response time (2 derivatives in two linear ranges, extremely low detection limit (39 nM), large Stokes shift (239 nm) and wide emission window gap (140 nm). In addition, the NBC structure was used as a fluorescent donor for FRET probes for the first time, which expanded the diversity of donors. Importantly, with low toxicity and good biocompatibility, the probe TFBN successfully detects exogenous and endogenous sulfites in living cells. These characteristics endow the probe TFBN can be successfully used in living cells and mouse imaging.

With high sensitivity and high selectivity formaldehyde bezek fluorescent double-channel indicator and use thereof

The invention relates to a high-sensitivity high-selectivity formaldehyde colorimetric fluorescence two-channel indicator and application thereof. The indicator is a kind of three-cyano dihydrofuran styrene compounds specifically and can be used as a formaldehyde colorimetric fluorescence indicator to be used for detection of formaldehyde. By utilizing the indicator, at least one of the technical effects can be realized, for example, formaldehyde can be identified with high sensitivity, formaldehyde can be subjected to qualitative and quantitative analysis in a manner of naked eye observation, formaldehyde can be subjected to quantitative analysis with a fluorescent spectrometry method, the indicator is stable in character and can be stored and used for long term, and the indicator has strong antijamming capability.