3807-80-5

Usage

Uses

Used in Disinfectant Applications:
3,6-DINITRO-1,8-NAPHTHALENEDICARBOXYLICANHYDRIDE is used as a disinfectant for its ability to eliminate or reduce the presence of microorganisms, such as bacteria, viruses, and fungi, on surfaces and in water. Its chemical structure allows it to disrupt the cell walls and membranes of these microorganisms, leading to their inactivation.
Used in Antiseptic Applications:
In the healthcare industry, 3,6-DINITRO-1,8-NAPHTHALENEDICARBOXYLICANHYDRIDE is used as an antiseptic to prevent infection in minor cuts, wounds, and burns. Its antimicrobial properties help to reduce the risk of infection and promote healing by killing or inhibiting the growth of harmful microorganisms on the skin.
Used in Chemical Synthesis:
3,6-DINITRO-1,8-NAPHTHALENEDICARBOXYLICANHYDRIDE can also be used as a starting material or intermediate in the synthesis of various chemical compounds, such as dyes, pigments, and pharmaceuticals. Its unique structure and functional groups make it a versatile building block for the development of new and innovative products.
Used in Research and Development:
Due to its unique chemical properties, 3,6-DINITRO-1,8-NAPHTHALENEDICARBOXYLICANHYDRIDE is utilized in research and development for the study of new chemical reactions, mechanisms, and applications. It can provide valuable insights into the behavior of similar compounds and contribute to the advancement of scientific knowledge in the field of organic chemistry.

InChI:InChI=1/C12H4N2O7/c15-11-8-3-6(13(17)18)1-5-2-7(14(19)20)4-9(10(5)8)12(16)21-11/h1-4H

Upstream product

• 81-84-5 1,8-Naphthalic anhydride 
• 53918-78-8 3,6-dinitro-naphthalene-1,8-dicarboxylic acid 
• 7697-37-2 nitric acid 
• 3027-38-1 3-nitro-1,8-naphthalic anhydride 

Downstream Products

• 1354701-65-7 N-(3'-amino-5'-carboxyphenyl)-3,6-dinitro-1,8-naphthalimide 
• 1354701-69-1 C₁₉H₁₄N₄O₄ 
• 1354701-62-4 N-(3',5'-dicarboxyphenyl)-3,6-dinitro-1,8-naphthalimide 
• 1354701-68-0 C₂₀H₁₃N₃O₆ 
• 330590-40-4 N-(4'-carboxyphenyl)-3,6-dinitro-1,8-naphthalimide 
• 1419321-06-4 3,6-dinitro-N-(4-aminobenzyl)-1,8-naphthalimide 
• 94985-13-4 N-[2-(Dimethylamino)ethyl]-3,6-dinitro-1,8-naphthalimide, Hydrochloride 
• 23986-31-4 3',6'-Dinitro-1,2-naphthoylen-benzimidazol 

Relevant academic research and scientific papers

Conjugated polymers based on 1,8-naphthalene monoimide with high electron mobility

1,4,8,9-Naphthalene diimides (NDIs) with strong electron accepting ability and high stability are excellent building blocks for semiconductor polymers. However, 1,8-naphthalene monoimide (NMI) with similar structure and energy levels as that of NDI has never been used to construct conjugated polymers because of synthetic difficulty. Herein, 3,6-dibromo-NMI (DBNMI) with bulky alkyl groups was obtained effectively in a four-step synthesis, and three donor-acceptor (D-A) type conjugated polymers based on NMI were firstly prepared. These polymers have strong absorption in the range of 300–600 nm, low LUMO level of 3.68 eV, and moderate bandgaps of 2.18 eV. Space charge limiting current measurements indicate these polymers are typical electron transporting materials, and the highest electron mobility is up to 5.8 × 10?3 cm2?V?1?s?1, which is close to the star acceptor based on NDI (N2200, 5.0 × 10?3 cm2?V?1?s?1).

Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands

A series of trisubstituted naphthalimides have been synthesized and evaluated as telomeric G-quadruplex ligands by biophysical methods. Affinity for telomeric G-quadruplex AGGG(TTAGGG)3 binding was first screened by fluorescence titrations. Subsequently, the interaction of the telomeric G-quadruplex with compounds showing the best affinity has been studied by isothermal titration calorimetry and UVmelting experiments. The two best compounds of the series tightly bind the telomeric quadruplex with a 2:1 drug/DNA stoichiometry. These derivatives have been further evaluated for their ability to inhibit telomerase by a TRAP assay and their pharmacological properties by treating melanoma (M14) and human lung cancer (A549) cell lines with increasing drug concentrations. A dose-dependent inhibition of cell proliferation was observed for all cellular lines during short-term treatment.

Identification of benzo[cd]indol-2(1H)-ones as novel Atg4B inhibitors via a structure-based virtual screening and a novel AlphaScreen assay

Targeting autophagy is a promising therapeutic strategy for cancer treatment. As a result, the identification of novel autophagy inhibitors is an emerging field of research. Herein, we report the development of a novel AlphaScreen HTS assay that combined

SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122

MicroRNAs are a class of endogenous regulators of gene function. Aberrant regulation of microRNAs has been linked to various human diseases, most importantly cancer. Small molecule intervention of microRNA misregulation has the potential to provide new th

Fluorescent labeling of specific protein targets in vitro and in vivo

New methods are provided for the post-genomic era that will permit the analysis of the dynamic expression and localization of gene products in living cells. Herein we propose the development of such a method from a bioorganic approach involving organic sy

Synthesis and characterization of dimaleimide fluorogens designed for specific labeling of proteins

A series of aromatic compounds were prepared bearing two maleimide groups attached directly to the fluorescent cores. The resulting derivatives do not fluoresce until the maleimide groups undergo their typical thiol addition reaction, thus removing their

Isoquinolones

Benzo[de]isoquinoline-1,3-dione of Formula or a pharmaceutically acceptable salt thereof wherein R is hydrogen or a protecting group typically used in the art for protecting alcohols and R1-R5are each independently chosen from H, Cl, Br, F, straight or branched alkyl C1-C8alkyl, C3-C8cycloalkyl, heterocycle or bridged heterocycle of 4-9 atoms containing 1-3 heteroatoms, —(CR′2)nOR6, —(CR′2)nN(R6)2, —(CR′2)nNR6COR7, —(CR′2)nNR6SO2OR7, —(CR′2)nNR6SO2N(R6)2, —(CR′2)nOSO2N(R6)2, —(CR′2)nCN, —(CR′2)n(NOR6)R7, NO2, CF3, —(CR′2)nSOmR7, —(CR′2)nSOmR7, —(CR′2)nCO2R6, —(CR′2)nCON(R6)2, Ph, and any two of R1-R5may form a substituted or unsubstituted ring of 5-7 total atoms having 0-2 heteroatoms are claimed which are selective inhibitors of bacterial DNA gyrase and DNA topoisomerase useful in antibacterial agents. Methods for their preparation and formulation as well as novel intermediates useful in the preparation of the final products are also claimed.

Reactions of isomeric dinitronaphthalic-1,8-anhydrides with alkylamines

In the reaction products of 4,5-dinitronaphthalic-1,8-anhydride and of the 3,6-dinitro analogue with 1-butylamine only nitro groups in the former compound undergo reaction. 2,5-Dinitronaphthalic anhydride reacted partially. 4,5-Dibutylaminonaphthalic-N-butyl-1,8-imide was moderately fluorescent by comparison with 4-butylamino-N-butyl-1,8-imide, (FBYR). The ease of nucleophilic replacement of the nitro group in mononitro substituted rings increases with ring size and appears to be related to the stability of a Meisenheimer intermediate.

Synthesis, structure and antitumor activity of new benz[d,e]isoquinoline-1,3-diones

New benz[d,e]isoquinoline-1,3-diones related to mitonafide (CAS 54824-17-8) and amonafide (CAS 69408-81-7) with double substitution on the chromophore and branched side chains have been synthesized and their biological activity determined. Molecular modeling studies of 3a based on X-ray crystallographic data of mitonafide have shown that the aromatic system intercalates between GC steps of DNA. The in vitro cytotoxic test data using CX-1 and LX-1 cells showed higher cytotoxic activities in disubstituted derivatives compared to both lead compounds. Some of the compounds have been selected for in vivo test using L1210 tumor cells and CX-1 cells. Two of them (3b and 3j) have shown promising activity as good candidates for clinical development.