380842-01-3

Basic information

• Product Name: 6-amino-5-cyano-3-methyl-2,4-dihydro-1'-ethylcarboxylspiro[pyrano[2,3-c]pyrazole-4,4'-piperidine]
• Synonyms: 6-amino-5-cyano-3-methyl-2,4-dihydro-1'-ethylcarboxylspiro[pyrano[2,3-c]pyrazole-4,4'-piperidine]
• CAS NO: 380842-01-3
• Molecular Formula: C15H19N5O3
• Molecular Weight: 317.34306
• Mol File: 380842-01-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 613.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 11.81±0.60(Predicted)
• CAS DataBase Reference: 6-amino-5-cyano-3-methyl-2,4-dihydro-1'-ethylcarboxylspiro[pyrano[2,3-c]pyrazole-4,4'-piperidine](CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-5-cyano-3-methyl-2,4-dihydro-1'-ethylcarboxylspiro[pyrano[2,3-c]pyrazole-4,4'-piperidine](380842-01-3)
• EPA Substance Registry System: 6-amino-5-cyano-3-methyl-2,4-dihydro-1'-ethylcarboxylspiro[pyrano[2,3-c]pyrazole-4,4'-piperidine](380842-01-3)

Safety Data

• Hazardous Substances Data: 380842-01-3(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 109-77-3 malononitrile 

Relevant articles and documents

A new convenient four-component synthesis of 6-amino-2H,4H-pyrano[2,3-c] pyrazole-5-carbonitriles and one-pot synthesis of 6′-amino-5′-cyano- 1,2-dihydrospiro- [(3H)-indole-3,4′-(4′H)-pyrano[2,3-c]pyrazol]-2- ones

A new convenient method for the synthesis of 6-amino-2H,4H-pyrano[2,3-c] pyrazole-5-carbonitriles, namely, four-component condensation of carbonyl compounds (aromatic aldehydes, heterocyclic ketones), malononitrile, ss-keto esters, and hydrazine hydrate in ethanol in the presence of triethylamine as a catalyst, which occurs selectively, is developed. One-pot two-step modification of this method is proposed for the synthesis of spiro[(3H)-indole-3,4′-(4′H)-pyrano[2,3-c]pyrazol]-2-ones.