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380844-26-8

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380844-26-8 Usage

General Description

Methyl 2-amino-5-(3-chloropropoxy)-4-methoxybenzoate is a chemical compound with the molecular formula C12H16ClNO4. It is a white crystalline solid that is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. Methyl 2-amino-5-(3-chloropropoxy)-4-methoxybenzoate has a variety of applications, including as a building block in the synthesis of other organic compounds due to its reactivity and functional groups. It is also utilized in the development of new drugs, as it can be modified to create derivatives with potential medical benefits. Additionally, it is used in the manufacturing of insecticides and herbicides due to its ability to act as a pesticide. Overall, methyl 2-amino-5-(3-chloropropoxy)-4-methoxybenzoate plays an important role in the production of various products for pharmaceutical and agricultural industries.

Check Digit Verification of cas no

The CAS Registry Mumber 380844-26-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,0,8,4 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 380844-26:
(8*3)+(7*8)+(6*0)+(5*8)+(4*4)+(3*4)+(2*2)+(1*6)=158
158 % 10 = 8
So 380844-26-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H16ClNO4/c1-16-10-7-9(14)8(12(15)17-2)6-11(10)18-5-3-4-13/h6-7H,3-5,14H2,1-2H3

380844-26-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 2-amino-5-(3-chloropropoxy)-4-methoxybenzoate

1.2 Other means of identification

Product number -
Other names Methyl 2-amino-5-(3-chloropropoxy)-4-Methoxybenzoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:380844-26-8 SDS

380844-26-8Relevant articles and documents

Anti-cancer drug gefitinib and analog intermediate electro-reduction preparation method thereof

-

Paragraph 0076-0079; 0080-0083, (2021/05/08)

The invention relates to an electroreduction preparation method of a 2-amino-4-methoxybenzoic acid derivative represented by a formula I, wherein the preparation reaction is defined in the specification, n is selected from 1, 2 and 3, X is selected from C

Design, synthesis, and in vitro antitumor activity evaluation of novel 4-pyrrylamino quinazoline derivatives

Wu, Xiaoqing,Li, Mingdong,Tang, Wenhua,Zheng, Youguang,Lian, Jiqin,Xu, Liang,Ji, Min

experimental part, p. 932 - 940 (2012/03/11)

Here, we describe the design and synthesis of two series of 4-pyrrylamino quinazolines as new analogs of the epidermal growth factor receptor inhibitor gefitinib. In vitro antitumor activity of these novel compounds against pancreatic (Miapaca2) and prostate (DU145) cancer cell lines was evaluated. Compared with the parental gefitinib, all 18 derivatives show a greatly increased cytotoxicity to cancer cells. In vitro kinase inhibitory activity on epidermal growth factor receptor was also investigated. Among them, compounds GI-6, GII-4, GII-6, GII-8, and GII-9 are more potential receptor tyrosine kinase (RTK) inhibitors. Based on these results, we propose simple structure-activity relationship to provide information for designing and developing more potent antitumor agents.

4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors

Holladay, Mark W.,Campbell, Brian T.,Rowbottom, Martin W.,Chao, Qi,Sprankle, Kelly G.,Lai, Andiliy G.,Abraham, Sunny,Setti, Eduardo,Faraoni, Raffaella,Tran, Lan,Armstrong, Robert C.,Gunawardane, Ruwanthi N.,Gardner, Michael F.,Cramer, Merryl D.,Gitnick, Dana,Ator, Mark A.,Dorsey, Bruce D.,Ruggeri, Bruce R.,Williams, Michael,Bhagwat, Shripad S.,James, Joyce

scheme or table, p. 5342 - 5346 (2011/10/09)

Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy) phenyl)urea hydrochloride) exhibits good pharmacokinetic properties in rat and mouse and is efficacious in a mouse tumor xenograft model following oral dosing.

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