380860-33-3Relevant articles and documents
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
Chen, Kai,Zhang, Shuo-Qing,Brandenberg, Oliver F.,Hong, Xin,Arnold, Frances H.
supporting information, p. 16402 - 16407 (2018/11/23)
We report a biocatalytic platform of engineered cytochrome P450 enzymes to carry out carbene-transfer reactions using a lactone-based carbene precursor. By simply altering the heme-ligating residue, we obtained two enzymes that catalyze olefin cyclopropan