38087-92-2Relevant academic research and scientific papers
Bulky Phosphane Ligand for Monoselective Ruthenium-Catalyzed, Directed o -C-H Arylation with Challenging Aryl Chlorides
Li, You-Gui,Wang, Zhen-Yu,Zou, Ya-Ling,So, Chau-Ming,Kwong, Fuk-Yee,Qin, Hua-Li,Kantchev, Eric Assen B.
, p. 499 - 503 (2017)
Functionalized aryl chlorides are more economically attractive but usually much more difficult as substrates in metal-mediated couplings than the corresponding bromides and iodides. A catalyst prepared from a bulky (biaryl)diphenyl phosphane and a common ruthenium source (1:1) mediates selective direct monoarylations of arenes bearing 2-pyridyl and related ortho-directing groups in good yields. Sequential arylations to heterodiarylated products also proceed in satisfactory yields.
Cobalt-Catalyzed C?H Functionalizations by Imidate Assistance with Aryl and Alkyl Chlorides
Mei, Ruhuai,Ackermann, Lutz
supporting information, p. 2443 - 2448 (2016/08/16)
A catalytic system comprising the inexpensive cobalt(II) acetylacetonate [Co(acac)2] and an N-heterocyclic carbene (NHC) ligand enabled versatile C?H arylations by oxazoline assistance. The broadly applicable, low-valent cobalt catalyst displayed a wide substrate scope, and even proved applicable to challenging C?H alkylations with β-hydrogen-containing primary and secondary alkyl chlorides. The power of the cobalt-catalyzed C?H arylation protocol was among others reflected by facile C?H activation at a room temperature of 23 °C, and efficient late-stage diversification, providing access to bioactive biaryls. (Figure presented.).
